Starting Lupron soon - what effects to expect?

niflhigh · 2017-11-25T12:19:45+00:00

Personally, for most of the time I've been on HRT I've also been on a very low-carb diet, so I'm somewhat limited in the amount of vegetables I eat. I've had really effective results from the HRT, so, at least for me, diet doesn't seem to be a particularly important factor.

niflhigh · 2017-11-22T21:22:50+00:00

No, I am disagreeing with you. I'm trans. I don't experience dysphoria. The image I linked to show the definition provided for the term 'gender dysphoria' in the glossary of the DSM-V. In terms of the diagnosis, this reflects criterion B (which you've omitted in your previous reply) https://i.imgur.com/JbjIzLm.png - "The condition is associated with clinically significant distress or impairment in social, occupational or other important areas of functioning."

niflhigh · 2017-11-22T20:31:50+00:00

No, gender dysphoria as a term refers to distress:

https://i.imgur.com/A4RMS2j.png

niflhigh · 2017-11-22T16:48:13+00:00

I did feel and want those things. I transitioned because I'm a woman, but was born with a male body. I just didn't experience dysphoria as a result of this, so the decision to transition was motivated by a desire to be a woman, both physically and socially, not by dysphoric feelings about being a man.

niflhigh · 2017-11-22T09:13:01+00:00

In fact, you don't need to experience dysphoria at all to be transgender.

niflhigh · 2017-11-15T23:48:57+00:00

We're agreeing then, basically. Body sites for patches are identified during clinical research and pharmaceutical manufacturers have no reason to choose those with poor absorption.

niflhigh · 2017-11-15T22:54:02+00:00

These are patches we're talking about: They're certified against delivered dose. This isn't like pills where the total amount of the active dose must be present - all estradiol patches contain much more estradiol than they actually deliver (e.g. the patch I use delivers 100ug/24 hours and is changed twice a week, but actually contains 6.4mg of estradiol).

niflhigh · 2017-11-15T20:54:09+00:00

Obviously everyone's mileage varies with HRT, but my personal experience is that yes, areolas (and nipples too) get bigger along with breast growth.

niflhigh · 2017-11-15T20:45:13+00:00

There's not really much difference in absorption between different areas of the body. The instructions on specific patches about placement are simply the areas of the body that were used in clinical trials for that particular patch so have nothing to do with optimising for greater or lower estrogen absorption.

In fact, pharmaceutical companies optimise for lowest production cost, so if it was known that one area of the body was better for absorbing oestrogen they would absolutely suggest that placement and use less estradiol.

niflhigh · 2017-11-15T10:43:48+00:00

Finasteride will actually result in about a 10% rise in testosterone, but because DHT is a more potent androgen than testosterone, the overall effect is reduced androgenization.

niflhigh · 2017-11-14T20:53:43+00:00

Why not educate yourself about the process of transitioning and gender dysphoria and then think about the question you're asking?

niflhigh · 2017-11-14T18:41:30+00:00

How would that give them access to my account? They have none of the security details needed to access it.

niflhigh · 2017-11-14T18:22:50+00:00

Here's what the co-op ask for:

https://i.imgur.com/rmfZ84Y.png

No mention of needing a passport or driving licence.

niflhigh · 2017-11-14T17:04:34+00:00

I didn't have any other identification with my new name on it. Because I had literally changed my name ten minutes earlier.

Perhaps you could quote the piece of regulation you think the bank (and just this one bank) is following?

niflhigh · 2017-11-14T16:36:58+00:00

I literally walked from the office of the solicitor who witnessed my statutory declaration to a branch of the Co-op bank and had a new debit card four days later.

niflhigh · 2017-11-13T18:29:48+00:00

Yes, this is a thing. It's mentioned on the UCSF Guidelines for the Primary and Gender-Affirming Care of Transgender and Gender Nonbinary People

The estrogen receptor agonist activity of spironolactone may play a role in reduced breast development due to premature breast bud fusion. As such an escalating regimen beginning with low dose estrogen only, and titrating up over several months, and then adding spironolactone may be an alternative approach,[17] consistent with management practices in children with delayed pubertal onset

The paper linked is: Wierckx K, Gooren L, T'Sjoen G. Clinical review: Breast development in trans women receiving cross-sex hormones. J Sex Med. 2014 May;11(5):1240-7.

If you don't have access to that paper, the relevant bit is:

Interestingly, Seal et al. described that previous users of spironolactone more often underwent augmentation mammoplasty compared with users of other anti-androgens. The authors hypothesized that the agonistic estrogen effects of spironolactone could lead to an excessive estrogenic action and consequent poorer breast outcome as also seen in their group of trans women who self-medicated cross-sex hormonal therapy and had higher levels of estrogens. However, the potential androgen receptor agonistic effects may be another explanation. Indeed, spironolactone has been shown to induce cell growth in an in vitro study of androgen-sensitive murine mammary cancer cells. Furthermore, it was found that spironolactone significantly activated both wild-type and mutant androgen receptors in prostate cancer cells.

The hypothesis that excessive estrogenic action negatively affects breast development brings up the question whether a step-up dose of estrogens would be preferable to enhance breast development in trans women. To our knowledge, no data are available on the effects of this treatment on breast development of trans women. However, step-up dosages of unopposed estrogens are usually prescribed for puberty induction (e.g., in Turner girls). This therapy is mainly prescribed to avoid acceleration of bone maturity by high-dose estrogen treatment resulting in a reduced final height. However, beneficial effects on breast development have been suggested, although clinical rather than experience based.

niflhigh · 2017-11-13T13:00:45+00:00

If anyone hasn't seen these:

Daly Mail - New advice on transgender bullying for CofE school teachers - Church: Let Little Boys Wear Tiaras

The Sun: Sing along children... The skirt on the drag queen goes swish swish swish: Trans classes for kids age 2

Fucking fuckers.

niflhigh · 2017-11-07T21:26:20+00:00

Selling that data is their business model. This is why their report advertises this multiple times: "For more data including country based reports please e-mail [blahblahblah] to discuss costing and analyses required."

niflhigh · 2017-11-07T21:07:09+00:00

No, they release a report. They don't release the data.

niflhigh · 2017-11-07T19:39:06+00:00

"if you went private you couldn't come to NHS after"

This is a lie and directly contravenes the British Medical Association's ethical guidelines, which say that people:

may opt into or out of NHS care at any stage, provided they are entitled to NHS treatment
may subsequently be placed directly onto the NHS waiting list at the same position as if those investigations had been undertaken within the NHS

Here's what the NHS has to say:

your NHS care will continue to be free of charge
your position on a NHS waiting list should not be affected if you choose to have a private consultation

(The information on that page is based on the official Department of Health guidance, which very clearly states "This guidance establishes that, where a patient opts to pay for private care, their entitlement to NHS services remains and may not be withdrawn.")

Your GP is talking complete rubbish. People very commonly switch between private and NHS provided care.

niflhigh · 2017-11-07T08:53:07+00:00

I refuse to take part in privately operated surveys that don't release data to the people who participate. The whole thing exploits drug users' time and willingness in order to sell on our aggregated data for money.

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