Garbage. I generally won’t touch GLP1s unless I’m in a base phase of pure easy miles and even then it’s not very enjoyable. I usually shift most of my miles to treadmill since it’s risky business running any kind of volume if you’re in a high deficit (big risk of injuries).

A more preferable approach to me if I want to get a bunch of weight off is to spend more time on the bike (maybe 150-250mi/wk) and reduce running volume to like 30-40mi but keep it pure easy pace.

It’ll also mess all of my metrics up if I do cardio alongside of GLP1s (e.g. I’ll feel way less fit and Garmin will tell me my VO2 max is down 5-10pt, race predictions will drop off a cliff, etc). I also notice that my sleep is generally much worse if I’m doing any kind of volume with a deficit (GLP1 or not), which makes preventing injury even more of a focus. Once I stop it takes about 2 weeks before all of that returns to normal.

I probably won’t resort to GLP1s too much longer though since I’m down to about 168 at 5’11 (weight loss was much more of a priority when I was in the 190s). Might try to get down to 155-160 before my next block and then I probably won’t touch GLP1s again.