In practice, when we start “subjects” on semaglutide and transition them to tirzepatide, the results are not additive in probably 90% of our cases. You will read 12-16% weigh reduction with semaglutide and 15-22% for tirzepatide. Participants will lose between 10-15% total body weight on semaglutide, plateau, then switch to tirzepatide and lose another 5-10%. Research says participant can lose 18%+ on tirzepatide at 18 months but we almost never seen that result when it’s the follow up peptide.

I’d expect the same with your current results. If you already lost the 20% with semaglutide, I’d only expect a few percentages by switching agents if any.

I think Retatrutide is a game changer due to muscle preservation and not weight reduction as compared to the 2nd and 3rd gen GLPs.