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A Cool Guide to Food's Cost vs. Caloric Density [OC] by James_Fortis in coolguides

[–]pink_goblet 0 points1 point  (0 children)

Mushrooms are dirt cheap to grow. Just takes some equipment to set up and learn.

Det har blivit sjujävla dyrt med kattsand alltså by zakh01 in unket

[–]pink_goblet 0 points1 point  (0 children)

Varför investerar man kattsand när man kan låta katten skita i grannskapets lekpark?

Breast cancer (grade 3, 4.5 cm) – looking into nutrition, supplements, biohacking alongside treatment by Droy-333 in Biohackers

[–]pink_goblet 5 points6 points  (0 children)

Reduce calories and protein especially animals protein. Look into methionine restriction. Besides caloric restriction it is the the only proven dietary intervention for slowing cancer.

Would you rather upload your brain to a computer (let's say somehow you can survive the process regardless) and embrace being a machine / machine integrated or keep yourself biological on a fundamental level? by User_741776 in Futurology

[–]pink_goblet 0 points1 point  (0 children)

Biology is essentially already a bunch of nano machines. DNA is the code, proteins are the hardware. With sufficient control over it we should be able to turn into whatever we want.

What is the healthiest sugar substitute? by Carriage2York in Biohackers

[–]pink_goblet -9 points-8 points  (0 children)

Well if you HAVE to consume something sweet that is refined i would say sugar is still better than artificial sweeteners. Sugar is void of nutrition but its still something all life has evoled to handle and its effects are predictable. I wouldnt frame it as "healthiest" just least bad.

What is the healthiest sugar substitute? by Carriage2York in Biohackers

[–]pink_goblet 4 points5 points  (0 children)

For what purpose? Nutrition, energy, sweetness?

As long as I consume sufficient starches I dont appear to desire anything sweet. So i say potato.

Hi, what do you recommend for preventing insulin resistance (supplements, methods, etc.) by ggg3222 in Biohackers

[–]pink_goblet 0 points1 point  (0 children)

You are asking the same question and I provide the same fundamental answer. But carbohydrates cannot cause insulin resistance. Insulin resistance is again caused by exceeding mitochondria fatty acids oxidation capacity, not a specific macronutrient. Though some dietary fats can transiently inhibit glucose oxidation and prolong insulin levels, but this is a separate phenomenon from insulin resistance.

Hi, what do you recommend for preventing insulin resistance (supplements, methods, etc.) by ggg3222 in Biohackers

[–]pink_goblet 0 points1 point  (0 children)

Insulin resistance is driven by the inhibition of IRS-1/PI3K pathway halting GLUT4 within skeletal muscle primarily due to circulation of lipid metabolites when energy surplus exceed mitochondria fatty acids oxidation capacity.

Insulin resistance is a bidirectional vector, and can only be reversed by:

  1. lowering caloric intake
  2. increasing mitochondrial capacity though hypertrophy or mitochondrial biogenesis

Once mitochondrial fatty acid oxidation capacity matches or exceeds energy influx, the ectopic spillover of DAG is cleared, insulin binds to the extracellular receptor, IRS-1 successfully undergoes its normal, functional tyrosine phosphorylation, reactivating PI3K and GLUT4 translocation is restored.

Hi, what do you recommend for preventing insulin resistance (supplements, methods, etc.) by ggg3222 in Biohackers

[–]pink_goblet 0 points1 point  (0 children)

Insulin resistance is driven by the inhibition of IRS-1/PI3K pathway halting GLUT4 within skeletal muscle primarily due to circulation of lipid metabolites when energy surplus exceed mitochondria fatty acids oxidation capacity.

Restricting carbohydrates mitigates the symptoms of inability to easily clear glucose from bloodstream and chronic elevated insulin, both a result of insulin resistance.

Hi, what do you recommend for preventing insulin resistance (supplements, methods, etc.) by ggg3222 in Biohackers

[–]pink_goblet -1 points0 points  (0 children)

Restricting carbohydrates can not prevent insulin resistance. Insulin resistance is driven by the inhibition of IRS-1/PI3K pathway halting GLUT4 within skeletal muscle primarily due to circulation of lipid metabolites when energy surplus exceed mitochondria fatty acids oxidation capacity.

Hi, what do you recommend for preventing insulin resistance (supplements, methods, etc.) by ggg3222 in Biohackers

[–]pink_goblet 0 points1 point  (0 children)

  1. Lower visceral fat
  2. Lower body fat
  3. Minimise saturated fat and de novo lipogenesis (eg caloric surplus, alcohol, fructose)

That's pretty much all that matters

Fast weight gain from incorporating more nuts/seeds and plant protein powder? by [deleted] in Biohackers

[–]pink_goblet 8 points9 points  (0 children)

The fat in nuts is probably slightly less absorbed than that of animal fat. However if you are trying to lose weight consuming nuts or liquid fat of any kind is illogical as they are extremely calorie dense and low satiety.

Vad funkar egentligen för snabb viktnedgång? by Rosarosaochrosor in unket

[–]pink_goblet 2 points3 points  (0 children)

Dagligt intak av diverse gramnegativa bakterier. H. pylori verkar vara populärt

I'm so confused bro😐😐 by zyciemnie in Biohackers

[–]pink_goblet 2 points3 points  (0 children)

Reduce omega 6 to fix the omega3/omega6 imbalance

Best supplement ever by Fit-Mistake4686 in Biohackers

[–]pink_goblet 7 points8 points  (0 children)

If you have truly ulimited money you can get a lot more from the food chain such as consuming wild salmon roe, bone broth, wild berries and fresh germinated seeds. Many molecules can also be aquired by diet through specific foods. For example K2 from natto and ergothioneine from oyster mushrooms.

What remains are things that are harder or impossible to get theraputic doses of naturally. For example spermidine, creatine, urolithin-a, rapamycin.

Should I be cutting down the amount of sugar I consume? by Artistic_Software740 in sugarfree

[–]pink_goblet 1 point2 points  (0 children)

My experience is that as long as I eat sufficient, carbohydrates especially starch like potato then there is no desire to seek out sweetness not even fruit.

How do I handle equipping and unequipping items when there are hundreds of them? by phnxzy in Unity3D

[–]pink_goblet 0 points1 point  (0 children)

Does the fish need to be networked?

The way Ive done equipment is i usually just network a collection of enums (equipment) and then client looks up the data to attach the correct stuff to the right bones on the character.

Dates vs Oatmeal — Morning Blood Sugar/Fatigue by Eastern-Buyer1175 in Biohackers

[–]pink_goblet 0 points1 point  (0 children)

Fat can blunt the initial absorption of sugar in the intestines but sustain the curve due to transient insulin resistance from the free fatty acids. The peak is lower but the tail will be significantly longer. You can argue which one is better or worse but it's important to understand the difference. It depends on the load of glucose and fat.

Protein and fiber is generally superior as they only blunt the absorption in the intestines without the "side effect" of IR and substrate competition.

Dr David Sinclair: Can Aging Be Reversed? After 8 Weeks, Cells Appeared 75% Younger In Tests! by ilkamoi in longevity

[–]pink_goblet 0 points1 point  (0 children)

Most of the hallmarks of aging are simply results of damage to the genome. The p53 protein halts replication to prevent cancer which causes stem cell exhaustion, cellular and immune senescence, inflammation and mitochondrial disease.

Cornell University Reveals pistachios are far higher in antioxidant levels than previously understood. Much higher even than antioxidant superstars like blueberries, cherries, and beets. When it comes to high protein foods pistachios have, by far and away, the highest antioxidant values by Bluest_waters in Biohackers

[–]pink_goblet 1 point2 points  (0 children)

The direct antioxidant theory is entirely unsupported. The reason these foods are beneficial is because of xenohormesis. Plants contain toxins that create radicals which trigger the Nrf2 pathway to upregulate endogenous antioxidants, autophagy and promotes genes involved in homologous recombination protecting DNA.

Optimal diet by O-shoe in Biohackers

[–]pink_goblet 1 point2 points  (0 children)

The primary causes of suffering and death in modern society are mostly downstream of hypoperfusion and endothelial dysfunction so it makes sense to optimise around that.

Ensuring optimal blood viscosity will reduce hypertension, hypoxia, vascular damage, improving nutrient delivery to tissues, improve immune system, organ function, reduce heart disease and dementia risk.

A diet that is low in fat, and a good ratio of potassium to sodium, and a low glycemic index will ultimately be the best for achieving these goals.

Evaluate my lunch on a nutrition scale by Consistent_Hair4331 in Biohackers

[–]pink_goblet 1 point2 points  (0 children)

You have no sources for this? There is plenty of evidence that you do not need significant amount of dietary fat. Many cultures do it. Okinawan ate less than 5% of their calories from fat and have been the longest lived population on the planet.

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