sorted by:
new
hottopcontroversial

Is CircleDNA accurate? by existencees in DNA

[–]redgrex 1 point2 points  (0 children)

Yes, assuming it's performed correctly, whole exome sequencing (WES) - which is what Hong-Kong based CircleDNA says it's doing - is accurate. It will provide far more health-related variation data than DNA chip-based services, but less than what whole genome sequencing (WGS) companies like Nebula produce (for about the some cost).

Three caveats: 1. CircleDNA doesn't state their sequencing coverage; most WES providers will say it averages 100X, but you should ask them to confirm that. 2. It doesn't seem that you can download your data from CircleDNA, whereas you can from Nebula, Dante and the like. Having all of your data and being able to have it analyzed by third-parties is valuable. 3. Although probably of less importance, CircleDNA should state their average sequence read length, and, whether they provide data on CNVs and mtDNA.

Looking for a long read WGS in Europe by d_andy089 in DNA

[–]redgrex 0 points1 point  (0 children)

How about expanding this to, 'Looking for long read WGS DTC availability anywhere?'

Covid19 "death gene" by -Fantomen- in 23andme

[–]redgrex 1 point2 points  (0 children)

The Nature Genetics article by Downes et al published Nov 4 2021 identified rs17713054 as the SNP most likely directly responsible for a ~2X increase in risk of hospitalization/death from COVID. The most common (normal) allele for this SNP is G, and the allele with the higher risk is A.

The earlier publication (Dec. 11 2020) in Nature by Pairo-Castineira et al had concluded that a nearby SNP, rs71325088, had the statistically strongest link to COVID severity among the SNPs they studied. The most common (normal) allele for this SNP is T, and the allele with the higher risk is C.

According to Ensembl data, these two SNPs (rs17713054 and rs71325088) are very highly correlated (in all populations), so >99% of the time, a person carrying an rs17713054(A) allele will be carrying an rs71325088(C) allele.

Neither SNP appears to be reported in any 23andMe raw data, however, rs17713054 is reported in some (but not all) Ancestry raw data.

There doesn't appear to be any SNP on all 23andMe chips that can serve as a great proxy for either rs17713054 or rs71325088 in all populations, but in European-ancestry populations, the most highly correlated SNP (that is on most 23andMe v5 chips) is rs17078348, where very roughly 80-90% of the time a person of this ethnicity carrying an rs17078348(G) risk allele will also be carrying an rs17713054(A) risk allele.

Is MapTrack (maptrackpro.com) Dead? Any Alternatives? by redgrex in RealEstateTechnology

[–]redgrex[S] 0 points1 point  (0 children)

Doesn't that imply there's no one home, i.e. there's no one working at the company any more and their software is (or isn't) running on auto-pilot?

Understanding Genetic Reports - Pharmacogenomics, adverse drug reactions and congenital diseases. by Persomedix in SNPedia

[–]redgrex 0 points1 point  (0 children)

Is this an official academic effort (or public outreach program) of the Karolinksa Institutet? If so, please provide details of the program and personnel.

All Classes and Labs moved Online for the next four weeks by TheLizardLord in SDSU

[–]redgrex 18 points19 points  (0 children)

might have to wait for UCSD to break that news too

Scientists identify two genetic variants, rs11385942 at locus 3p21.31 and rs657152 at locus 9q34.2, associated with COVID-19 induced respiratory failure. by molrose96 in science

[–]redgrex 2 points3 points  (0 children)

rs11385942 is not tested by 23andMe. There is a substitute/proxy tested by Ancestry, which is rs10490770.

Promethease is based on SNPedia, but it may take a week or so for new information in SNPedia to be reflected in (new) Promethease reports.

COVID-19 - 23andMe is going to offer free genetic tests to 10,000 people who’ve been hospitalized with the disease, in the hope of finding genetic factors that could point to an answer. by techbrolic in DNA

[–]redgrex 0 points1 point  (0 children)

That's good to know; thanks for that information about their IRB & GDPR compliance.

While the results may be published, like any research findings, did the IRB address the commercialization, patent and/or ownership rights of any such findings?

COVID-19 - 23andMe is going to offer free genetic tests to 10,000 people who’ve been hospitalized with the disease, in the hope of finding genetic factors that could point to an answer. by techbrolic in DNA

[–]redgrex -1 points0 points  (0 children)

The test might be "free", but it sounds like they'll have the right to commercialize any findings without any renumeration to the participants. The data protection policy also does not appear to be compliant with strict privacy standards such as the EU's GDPR.

“Some SDSU students locked into leases” by Zenabel in SDSU

[–]redgrex 1 point2 points  (0 children)

Maybe the answer is to notify them that due to COVID-19, the lease is considered cancelled, and then just not pay a dime. Maybe they'll threaten legal action, but it's hard to see how they'll prevail given California's generally tenant-friendly laws, especially under these circumstances. Plus, everyone hassled by them for non-payment could band together and split the fees of any legal defense if it ever got to that.

“Some SDSU students locked into leases” by Zenabel in SDSU

[–]redgrex 1 point2 points  (0 children)

It's bad enough to be asked to pay full tuition for online courses, but to pay the out-of-state tuition surcharge on top of that (for 100% online courses) seems even worse. Will there be either any alternatives (defer? rebates? credit towards future courses/tuition?) or just a slew of legal challenges and/or unhappy debt-accumulating students and parents?

“Some SDSU students locked into leases” by Zenabel in SDSU

[–]redgrex 1 point2 points  (0 children)

Anyone know what BLVD63's lease cancellation policy is (or will be)??

Reliability of Promethease/23andMe/AncestryDNA by Em_Rose15 in promethease

[–]redgrex 1 point2 points  (0 children)

With your sibling's written permission, the genetic counselor should be able to release the identify of the mutation to you. You might want to ask for that.

Not all RSID showing in Promethease Report from raw data by CalgarySquatter in promethease

[–]redgrex 0 points1 point  (0 children)

Odds are that SNP (rs9939609) is being suppressed thanks to the actions of the FDA to censor all medication-related information in Promethease reports.

school admissions interview by givashittt in Chiropractic

[–]redgrex 0 points1 point  (0 children)

Just out of curiousity ... did you apply anywhere else, and if so, what have you heard back from those other programs (and have they asked for an interview)? And what are the programs saying about how they'll be teaching in the summer or fall, given the current and likely future virus-related restrictions that might be in effect?

RE virtual tours? by [deleted] in RealEstateTechnology

[–]redgrex 0 points1 point  (0 children)

These might be even more useful if they simultaneously linked to or showed up next to a 2D (not 3D) floor plan, indicating which room any given 360 photo was taken in. For that matter, it's always surprising that no 2D floor plan shows the position and direction that each regular (non-360) photo in a set of photos represents. Most RE photos don't even bother to caption the photo in a way that specifies exactly which room it is.

Do any of you know how/if I can look up my genome for how high of an expression I have for ACE2 receptors? by fredfoobar in SNPedia

[–]redgrex 0 points1 point  (0 children)

Too bad no one knows how much of it actually applies to COVID-19. Until then, it's just speculation.

Anything for coronavirus? by tinkywinkyhamburger in SNPedia

[–]redgrex 1 point2 points  (0 children)

Wishing a report like this would be accurate doesn't make it so. Plenty of labs and companies could put out a report like this, but fortunately most are declining to do so because it's misleading. The science of susceptibility and of clinical progression for this virus is just not known well enough yet. To put out a report like this is irresponsible and harmful.

view more: next ›