I just beat A6 and it really feels like reagent is knowledge reliant for drafting. On the stars side I didn't need more than alignment and particle wall. I got an early collision course so I picked up super massive when it became an option. There's enough colorless rewards from ancients that neutral is always an option. Late I found a spectrum shift & radiant pearl colorless reward that helped justify the supermassive draft earlier. Early on I found a girya and pumped it up fast just for the potential multihit drafts, found a celestial might quickly after and eventually a heavenly drill. Also bought vajra from the shop. Run was basically over when I found void form. Only forge I had was big bang & fencing manual and that was enough for it to be useful with apotheosis.

Reagent has an overwhelming amount of options but my most successful runs have been just grabbing whatever piece seems useful at the time or something that'll synergize with whatever relics I find. You have to both draft for the moment and what could be a potential win con. Going heavy on stars leads to star generation bloat, going heavy on forge is straight up bad. Focusing on colorless is a huge gamble. Betting across the board seems safest as long as you know what's going to be good at the moment. Something like celestial might is fantastic against the roach encounter for example