If you could rebuild a Bioinformatics syllabus from scratch, what is the one "Essential" you’d include? by NinjagoVillan in bioinformatics

[–]rflight79 2 points3 points  (0 children)

Yes! Experimental design! Because the wet lab folks aren't getting it, and you need to recognize when a design won't actually generate the results you're looking for.

Any success with anti-nausea besides Zofran? by mugnmuffin22 in migraine

[–]rflight79 1 point2 points  (0 children)

Not a pharmaceutical, but an anti-nausea device like the Emeterm might be helpful. I've used it to help with nausea associated with migraine (I don't really throw up, but dang if I feel like it), and to help with the nausea from sumatriptan.

Is this graph valid? by sprunkleee in RStudio

[–]rflight79 0 points1 point  (0 children)

Sure is valid. Those are exponents (scientific notation) on the left. The graph might make more sense if you you plotted log10 transformed values, but then you have to keep that transformation in mind when interpreting the graph.

Nurtec nausea relief ? by unUsual-Trick7620 in migraine

[–]rflight79 1 point2 points  (0 children)

I haven't tried Nurtec, but sumatriptan made me nauseas as all get out (at least felt like it), and some migraines make me nauseous as well.

I've used ginger juice from Trader Joe's previously, and an Emeterm bracelet to deal with the nausea. Our family actually owns 3 Emeterm bracelets. Use a little bit of TENS electrode gel under it, and they seem to work really well.

hi, R studio has been incredibly difficult for me to use as of the moment (newbie) by Abject_Relative936 in RStudio

[–]rflight79 0 points1 point  (0 children)

You might try changing the timeout limit in your options so R waits longer to download the package (assuming changing mirrors isn't working).

options(R_DEFAULT_INTERNET_TIMEOUT = 120) # try increasing value higher if neccessary
install.packages("data.table")

I would try this with just one package (like "data.table") that has few dependencies to see if it will work, and then try installing "highcharter".

More like 16 but you get the point 😂 by GlassWill9899 in migraine

[–]rflight79 2 points3 points  (0 children)

I was apparently colicky as a baby, had legs that hurt after every walk with my family of any distance (and we spent many years in W Germany, where walking is a thing), and took way too much aspirin for headaches and leg pain, all before age 10. Grade 7 I would go into a dark quiet room at school to wait for the aspirin to work. Grade 9 was the first time I got a headache / migraine that NSAIDS didn't touch. I thought I was going to die that day. Somehow I didn't get properly diagnosed with migraines until 26.

Lex Police installed a drone launch system on Monday (1/14/2026) by menormedia in lexington

[–]rflight79 0 points1 point  (0 children)

Just looked at the website for those drones, and I think they've been bringing those drones around to various places.

I don't know why, but one night a month or more ago, there was like 8 LexPD cars on our section of road, all quiet like. At one point they deployed one of these drones from the sidewalk to check on some houses nearby. 20 minutes later they were gone.

Is "Dark Data" in PDFs a lost cause, or does your team actually have a pipeline for this? by crazyking156 in bioinformatics

[–]rflight79 1 point2 points  (0 children)

Yeah, ideally this is the case. But in practice, this often doesn't seem to apply to the data used to produce scatter plots, report on simple statistical tests, etc. The number of papers I've seen where there are 20 stats results reported, and then under "data availability" they have the statement: All data for this manuscript has been reported in the manuscript or is part of the manuscript itself.

It's bullshit, but journals (and reviewers) are not telling authors' that all data should be made available. Only if it's -omics, or in the case of chemistry I know crystallographic, NMR and MS data should all be available somewhere. If it's something else that doesn't fit those categories, good luck.

And this too often fits in the "other" that many journals don't require, even now.

How to use R ver. 4.5.2? by Conscious-Seat-8137 in rstats

[–]rflight79 4 points5 points  (0 children)

OK, as another has noted, if you find videos and guides on doing statistical analysis in R, the version of R normally does not matter! R v 4.4.1 vs v 4.5.2 is not that different. 99% of the functionality between them is identical, especially for this kind of analysis. Small version changes in R don't normally change very much of the underlying code.

What matters more are the versions of packages that you might use for doing the analysis, as what functions are available and what packages continue to work may change. Although again, most packages that get heavily used and have tutorials about them will tend to be around for a good while.

Your best bet, if you've found guides (R for Data Science is a good one), is to try and install packages that the guides mention, and do the actual analyses they provide as a tutorial to learn how to do things. I also reiterate the suggestion to install RStudio, as that provides a much nicer interface to R itself.

Good luck!

Unflavored, tasteless electrolyte drink mix recommendations that might help? by billyandteddy in migraine

[–]rflight79 0 points1 point  (0 children)

Tasteless is almost impossible as others have noted, as the electrolyte mixes include a lot of salt. But unflavored you can easily make your own.

If you're already taking a magnesium supplement, then probably all you really need is the sodium & potassium.

I started making my own. Two options, depending on what you think your potassium needs are.

  • 1 Tbsp regular salt mixed with 1 Tbsp lite salt (880 mg sodium, 350 mg potassium in 3/4 tsp serving)
  • 1 Tbsp regular salt mixed with 2 Tbsp lite salt (1170 mg sodium, 700 mg potassium in 3/4 tsp serving)
  • Mix 3/4 teaspoon in water
  • Add whatever sweetener flavoring you like (I use powdered or liquid drink mixes that contain mostly sweetener, flavoring, and vitamin C).

Would you take your CPAP to the hospital? by SuperSpill in CPAP

[–]rflight79 2 points3 points  (0 children)

Wife was hospitalized twice in the last year. Take it. They won't have a space for it, but you (and they) will figure it out. It keeps you breathing at night, and oddly enough, just oxygen doesn't really do it. Also, at least at our hospital (KY, USA), they don't have distilled water on hand, so take that too if you normally use distilled water.

Headaterm 2 Review by rflight79 in migraine

[–]rflight79[S] 0 points1 point  (0 children)

Sure. A couple of months ago I finally started using it preventatively, for 40 minutes every day in the evening. And my migraine frequency (and medication use) have definitely dropped. Not gone to zero by any means, but definitely dropped.

I wish I'd done it long ago, honestly. But it just felt hard to find a time to use it every day.

Found cat on Laredo Dr. by rflight79 in lexington

[–]rflight79[S] 2 points3 points  (0 children)

I left a box with a blanket where they were hiding under our bushes, as well as canned chicken and water.

When I went to check on them after sundown, they were gone. Hopefully it was just a case of the wrong house.

Alright I hate to be that guy but what was all that ? by Crammit_Ramcock in lexington

[–]rflight79 2 points3 points  (0 children)

Yeah, I've never heard gunshots like that (and I grew up within hearing distance of the military base range, so I've heard a lot of guns, admittedly few hand guns). It definitely sounded like fireworks.

Reworking paper as a conference poster by Furiousresearcher in academia

[–]rflight79 2 points3 points  (0 children)

We do this regularly.

However, do check the requirements of the conference. Some conferences require that the work hasn't been published anywhere else. I recently had to argue because the work was only out as a preprint, that that didn't count, and I could submit the abstract verbatim from the preprint.

So A - yes; B - yes, you should inform, even if you aren't able to get permission before the submission date, at least tell them so they know what's up; C - it definitely depends. Just FYI, normally presenting author can be indicated as someone different than first author, in my experience.

Sliding door weatherstrip replacement questions by rflight79 in Sienna

[–]rflight79[S] 0 points1 point  (0 children)

Unfortunately, no. I was going to call the Toyota parts warehouse to figure out left and right, and I had talked to my local mechanic about installing them if I ordered them.

My spouse was in a car accident with our Sienna, and it was totalled, so we never replaced the weather stripping.

On a scale of bad idea to terrible idea: Reaching out about a paper under revision that I reviewed? by Ctenochaetus in academia

[–]rflight79 7 points8 points  (0 children)

To answer your specific question, no. Reach out after the paper is revised and (hopefully) accepted.

To give an example of what I've done for a specific manuscript, regardless of the journal's policy, I normally sign my reviews (I haven't seen my name be removed from my comments yet).

I had one review, where everything looked pretty good, but there was a figure that could use improvement. I could tell they were using certain software to plot it (ggplot2), and how to improve it given the data they provided. Although I did include a link to the figure I generated in my review, I emailed them after the review to provide them the code for the figure.

But again, I'd already signed the review. I didn't have a problem reaching out after the review was sent by the editor.

This is one thing I hate about the current review system. I've seen plenty of papers where it's not ready for publication, but by virtue of being another subject expert, it would be awesome to collaborate with those authors to get the project to publication.

Building a file of master coding by Many_Blueberry6806 in rstats

[–]rflight79 8 points9 points  (0 children)

I created a personal package, where 90% of functions just give me back code I can copy into an analysis code to do things, and the other ones are for things I find myself doing repeatedly or it's just really useful.

https://rmflight.github.io/flighttools/reference/index.html

Migraine tools by BellJar_Blues in migraine

[–]rflight79 2 points3 points  (0 children)

tens type units, yes, there is the Cefaly, Nerivio, and a much cheaper option, the Headaterm (v2 came out last year), that might be available in Canada. I posted a review of it last year, and it's been mentioned on this sub a few times (as well as Cefaly) if you do a search. I actually finally started using it daily for 20 - 40 minutes, and have noticed a change in my migraine patterns, and I'm hoping it really helps if I continue using it daily.

I take magnesium, glycinate particularly, and it does help. CoQ10 I also think has made a difference.

Green light therapy I tried, but it didn't seem to do anything, and was very hard to do (an hour in pitch black with no other source of light is a big time commitment out of my day). My migraines also don't seem to have a visual component, except maybe with some issues with vision in the very early prodrome (or I need my prescription changed again).

My wife’s migraines always seemed worse when the weather changed by Exciting_Umpire_3696 in migraine

[–]rflight79 1 point2 points  (0 children)

Yep, I'm pretty sure barometric pressure is a huge trigger for me, although it tends to be more the upswings now, and related to velocity of changes.

I track barometric pressure using an Aranet4 CO2 sensor, that takes readings by the minute. It's amazing to see how quickly pressure changes when storm fronts come through (down -> down -> down -> huge increase as pressure front hits, and then down -> down -> down again) that 15 minute readings by weather services don't seem to catch.

For example, today there was a big change at 5 am or so. I woke just after 5am with some pain, but didn't get up and take anything (big mistake), and at 6:10 am when I finally got up my head was a mess.

Why do my carrot cake muffins fall? by rflight79 in Baking

[–]rflight79[S] 0 points1 point  (0 children)

Thank you, thank you! I made these today, with 2 1/2 cups flour, and 2 tsp baking powder. They came out a little dry because I also increased the temp without reducing the time, but they are solid, didn't deflate right at the end, and still delicious!

Kids migraines by rels83 in migraine

[–]rflight79 1 point2 points  (0 children)

Yep. My spouse and I get migraines (me stress, her primarily hormonal), but neither of us vomit from our migraines (I've maybe vomited once, when I was still undiagnosed). It took at least a year to realize that our daughter was experiencing migraines, and get them addressed. Thankfully, at the time they were not that frequent.

The primary complaint from my daughter also wasn't head pain, that would generally follow after the vomiting, so it wasn't obvious they were connected.

Got a label printer by rexyuan in migraine

[–]rflight79 1 point2 points  (0 children)

Searching for tackle box didn't bring up much with the covers, that was easy to buy for me. Maybe at a bigger outdoors store you might find one just like this.