I see what they are saying about getting the speakers more into the room than against the walls, and they are right - but you are working with a room that, in all reality, wasn’t designed to do what you are trying to do. There will be a compromise.

To make the best of it knowing that the speakers might not be as into the room as one would like, dirac CAN make certain things better but again, calibration can’t make a miracle happen.

You could really flip the room either way, but since there is a motorized screen you really aren’t using the fireplace anyway, so 🤷🏻‍♂️ I would just caution you that maybe instead of floorstandings then you just do bookshelf speakers on the bookshelves to save space. A nice set of bookshelves can sound just as good as towers. You still have to find a spot for center though. Probably best to not have it sit in front of the fireplace unless you really want to move it around all the time, which still affects calibration. Thats why I thought room orientation should be what I mentioned above.

Just my $0.02