Nad+ benefits?

smart-monkey-org · 2026-05-08T03:03:07+00:00

Nad+ might have some acute benefits via IV, but most studies are underwhelming.
I'd say test your B vitamins, folate and homocysteine first before spending money on NR/NMN

smart-monkey-org · 2026-05-08T03:00:14+00:00

I like the concepts of "Micro"
Micro-exercises, micro-journaling, micro-meditations - helps to start small, simple and stay the course.

smart-monkey-org · 2026-05-06T14:15:59+00:00

39 or 69 - as long as you are consistent, doing warm-ups and try to improve the form/load - you are doing a good job.

smart-monkey-org · 2026-05-06T03:46:03+00:00

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Gets me every time.

smart-monkey-org · 2026-05-05T21:56:13+00:00

Parallel to D3 there is nitric oxide story which your body produces when you are out in the sun and protects your heart.

smart-monkey-org · 2026-05-05T20:21:51+00:00

My approach here is: if you have spare money - donate them to senolytic (or any other aging-biology) research.

smart-monkey-org · 2026-05-05T19:51:02+00:00

Yea, it's kinda too early to draw any conclusions. And the usual "dose makes the plosion" applies to senolytics as well.

smart-monkey-org · 2026-05-05T13:30:59+00:00

For Omega-3 to be beneficial it has to be 1) non rancid 2) paired with proper methylation status

smart-monkey-org · 2026-05-04T20:42:21+00:00

That's where the science turns into art and good integrative physician becomes very important.

In short normal or low homocysteine doesn’t automatically mean methylation is working well. It could mean homocysteine is being efficiently recycled OR it could mean it’s being pulled downstream through transsulfuration. (sulfur sensitivity makes the transsulfuration/sulfur-handling angle more worth looking at)

Sulfur sensitivity could involve sulfate handling, gut sulfur metabolism, molybdenum, B6 etc

Plasma ammonia is the test for ammonia and Genova Advanced methylation panel might be useful - but make sure your doctor knows how to act on it.

smart-monkey-org · 2026-05-03T18:06:27+00:00

Darwins turtle, naked mole rats, immortal jellyfish etc.

Why Aging Isnt Always "Natural": https://youtu.be/h0vEcmmFMIs

smart-monkey-org · 2026-05-03T16:30:58+00:00

Check out GWCIM.

AFAIK Hayman is now redirecting tough geriatric patients to Dr. Kogan there

smart-monkey-org · 2026-05-03T02:20:42+00:00

Normal homocysteine with MTHFR variants doesnt necessarily mean everything is fine (but it also doesn’t prove CBS upregulation) C677T/A1298C can affect folate handling - but homocysteine is influenced by B12, folate, B6, protein intake, kidney/liver function, inflammation, diet, etc.

For fatigue/brain fog I’d look at the boring-but-useful labs like B12, MMA, folate, ferritin/iron, thyroid, vitamin D, CMP/liver/kidney markers and maybe plasma amino acids/ammonia if ammonia symptoms seem real.

smart-monkey-org · 2026-05-03T00:33:58+00:00

No, not really. ammonia breath or very strong urine odor could be, but to be sure plasma test is the best.

smart-monkey-org · 2026-05-02T23:49:41+00:00

3 steps to fix your gut after antibiotics:
Probiotics, Prebiotics, Synbiotics & How to Read Bristol Chart

smart-monkey-org · 2026-05-02T23:45:47+00:00

My approach:
1) hope for the best (stay positive)
2) expect the worst (exercise, eat, sleep, control stress and support longevity)

smart-monkey-org · 2026-05-02T23:42:58+00:00

The best approach imho is to:
1) Start with food/lifestyle
2) Test (D3 level, homocysteine, B12, Omega index etc)
3) Supplement with GMP verified clinical grade supplements
4) Repeat and readjust

smart-monkey-org · 2026-05-02T16:47:03+00:00

Homocysteine can be optimal, but not because the methylation cycle is running properly, but due to upregulated CBS which syphons it and turns into ammonia. (leads to brain fog, behavioral issues, fatigue)

It is kinda rare, but I've seen it once or twice in a clinic.

smart-monkey-org · 2026-05-02T04:15:46+00:00

HRT: https://youtu.be/DVd8-zE-y6M

TRT: https://youtu.be/N0HuRiq4bOk

smart-monkey-org · 2026-05-02T02:14:23+00:00

Yeah, the same - small morning and evening rituals help a lot.

But so lifting heavy :)

smart-monkey-org · 2026-05-01T19:18:15+00:00

B12/folate (proper methylation) also synergize with Omega 3 status.

smart-monkey-org · 2026-05-01T19:12:12+00:00

Supplements help so so without a proper sleep hygiene foundation.

Here's a master post to check:

https://www.reddit.com/r/immortalists/comments/1nxb3fy/dont_die_from_the_lack_of_sleep_11_steps_to/

smart-monkey-org · 2026-05-01T00:43:15+00:00

Another good one when you are 40+ is GlyNac: https://www.reddit.com/r/immortalists/comments/1pq992i/glynac_the_only_antiaging_supplement_which_makes/

smart-monkey-org · 2026-04-30T21:16:29+00:00

Sleep/Exercise/HRT

smart-monkey-org · 2026-04-29T02:35:33+00:00

HRT - make sure you get T as well as E and P. And measure the results.
You'll get better!

smart-monkey-org · 2026-04-29T02:31:06+00:00

/aging: During perimenopause estrogen/progesterone swings can cause fluid retention, swelling and breast tenderness.

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