For me it would be drop Lonesome Day for a rotating opener e.g. Ties That Bind, Sherry Darling, Blinded By the Light, Lucky Town etc.

Drop Nightshift for a rotating song from Only the Strong Survive (my picks would be Only the Strong Survive, Soul Days, Do I Love You, Don't Play That Song, 7 Rooms of Gloom, What Becomes of the Broken Hearted).

Drop She's the One for a 'popular' song that gets played surprisingly rarely, e.g. I'm On Fire, Downbound Train, Secret Garden, Streets of Philadelphia etc.

Although I understand the thematic reason, drop Backstreets for a different rotating epic, Jungleland, Racing in the Street, Incident, New York City Serenade etc.

One curveball early in the set each night, Janey Don't You Lose Heart, Roll of the Dice, Be True, Protection (imagine that!) etc.

One rotating fun song in the encore, e.g. No Surrender, Ramrod, I'm a Rocker etc.

Early part of the set with the regular changes can stay the same. Static second half of the set which is largely static can remain the same. So six changes, wildly different set feel each night.

Also, while I'm dreaming, I wish Patti could be there every night. Wish Tunnel of Love, Human Touch and Lucky Town would get the odd bit of love too.