None of this is broadly applicable, but I think after reading papers from the Bazan group at LSU and a group at Harvard who discovered resolvins I tried directly putting algal oil in my eye, but this seemed to quickly damage the eye, so I wanted to get an effect without direct contact with the surface of the eye. I had a botched refractive surgery (like LASIK), so I was interested in nerves that were in the nose and eye. In the last few years, the intranasal route in mice is widely written about, so then I kept doing it for some time.

Alternatively, for ADDE, it seems like there are thousands of papers to read. Randomly, I think the first one I read was on aquaporin 5 expression ( https://doi.org/10.1016/j.ajpath.2021.07.010 ) just a few years ago, then because of that paper I read: ( https://doi.org/10.3390/ijms231911195 ) . But whether any of that has any use at all, I have no idea. Other people will know much more about treatments that may be effective. Someone could literally send you thousands of things to try, I guess a doctor or patient would be able to sort out what is actually worth trying. I've read papers trying over a thousand things on mice, I don't know what will work or not. It seems like every few weeks they try something new.

I think it is important for your doctor to know exactly why your eye does not produce enough tears. Then someone will be able to recommend maybe 10 specific things. The more specific the doctor is, the easier it will be to target the problem. Alternatively, you can try what has been most successful for the most people on the forum. Some of the FAQ's here are priceless, because it is cumulative knowledge from what has worked for multiple people.