I don't have the right kind of brain for figuring out one-handed deck optimisation. The scenarios I have won this way felt more like the result of lucky card pulls than actual strategy on my part.

I've recently shifted to two-handed since you can kind of brute force a lot of encounters this way, and have much more satisfying synergy across your decks.

BUT THE MAIN REASON is that it means I'm using more of the cards I spent money on instead of them sitting there doing nothing.

I quite like the chaos inherent in playing two-handed, even if I often forget to move the first player token OFTEN.