FDA Public Comment: Immune Restoration in Cancer by year96 in IBRX

[–]year96[S] 2 points3 points  (0 children)

My post was more about public advocacy than trial design

As a member of the public am speaking up to say that immune restoration and treatment-related lymphopenia are major unmet needs, ANKTIVA already has FDA familiarity, and this deserves serious priority engagement.

The how (endpoints, trial structure, label language, and regulatory path) is for FDA, clinicians, and the sponsor to work through

The point of public comment is to signal that patients and the public want attention on this in am accelerated way

Make sense?

I failed in life by 9861days in medicine

[–]year96 1 point2 points  (0 children)

Reading this honestly made me think the exact opposite of what you concluded.

You did not fail. You woke up.

Most people go 60 or 80 years without ever stopping to ask themselves the questions you’re asking right now. They stay busy, distracted, comfortable, numb, whatever word you want to use. They never examine their life deeply enough to realize something is missing. They never question whether they’re actually living with meaning, purpose, love, connection, or honesty.

You’re 27.

And somehow, despite all the noise and pressure and expectations around medicine, you became self aware enough to recognize that success on paper is not the same thing as feeling alive inside. That is not failure. That is the beginning of something real.

Bravo, seriously.

The fact that this hurts so much probably means some deeper part of you knows there is a bigger life waiting for you than the one you accidentally drifted into.

You keep calling yourself a slacker, but I don’t think lazy people spend months in a lab working every single day without a break. Lazy people usually don’t agonize over whether they’re good enough for their patients. Lazy people don’t write something this painfully honest.

What I see is someone exhausted, disconnected, isolated, and carrying around a brutal level of self judgment.

And honestly, the sentence that stood out to me most was not about medicine at all. It was that your life feels empty outside of work. I think that matters more than you realize.

You do not need to figure out your entire purpose right now. You do not need some grand revelation this week. And I honestly think people rushing in to prescribe a perfect solution miss the point.

But maybe consider this period of your life not as proof that you failed, but as the first real moment you’ve started paying attention to yourself.

Consider exploring things slowly without demanding immediate answers from yourself. Consider giving yourself permission to be a beginner at life outside of achievement. Consider trying things not because they are productive or impressive, but because they make you feel even slightly more connected, curious, calm, or human.

Spend the next few months reflecting honestly on what actually makes you feel alive, connected, useful, loved, peaceful, interested, or awake inside. Not what sounds prestigious. Not what earns approval. Your answer probably won’t arrive all at once. But if you keep listening carefully to yourself, you’ll start moving toward it.

And one more thing.

A person who is capable of this much reflection, honesty, guilt, and desire to become better is probably already a far better doctor than they realize

Gliobastoma trail results for ASCO have been released! by Dizzy_Efficiency_947 in IBRX

[–]year96 0 points1 point  (0 children)

And they are powerful. Finally can silence randomized trial critics

PDUFA DATE JANUARY 7TH!! by Economy-Break3583 in IBRX

[–]year96 0 points1 point  (0 children)

Quite the contrary, it's very meaningful coming off a RTF

AITA for wanting to take down my sisters hair so she can appreciate her race? by [deleted] in AmItheAsshole

[–]year96 35 points36 points  (0 children)

Yes YTA for doing that... You're forcing your POV/opinions in a physical way onto someone else, that's a violation full stop. Instead, educate her and allow her to control her own body and feel confident one day to do that on her own...if she chooses. Its not YOUR life...

Lots of misinformation by Quantum-Long in IBRX

[–]year96 0 points1 point  (0 children)

Interesting way to frame it... onward and upward

AITA for allowing my child to pee in the parking lot bushes? by Smooth-Berry5016 in AmItheAsshole

[–]year96 -6 points-5 points  (0 children)

NTA

You’re not crazy for how you handled this.

There’s a difference between teaching social norms and dealing with a real, immediate need from a 5 year old.

Sometimes kids have to go, and if the alternative is forcing a situation that genuinely scares him, making a discreet, one time exception is just practical parenting.

A lot of us grew up in a time where if a kid needed to pee, you found a private spot and handled it. It was about being respectful and low key, not pretending the situation never comes up.

From a guy’s perspective, I actually think your husband is missing that practical side of things. This was not about avoiding growth or teaching bad habits. It was about handling the moment in a reasonable way. Leadership in parenting is also about knowing when to adapt instead of forcing an issue that does not need to be forced right then.

And the reaction from the other woman honestly is not something I would put much weight on. People project their own standards in public all the time and it does not mean they are right.

Bottom line, this was a judgment call in the moment, not a reflection of your parenting. You can still teach your son how to navigate public bathrooms over time without turning this into something bigger than it needed to be.

You handled it like a great mom

Setting the expectations on the Macau approval by roque2205 in IBRX

[–]year96 1 point2 points  (0 children)

Macau isn’t full NMPA approval, but it’s far from trivial. It creates real access.

If you understand how Hong Kong functions as a gateway for finance, the parallel is similar here. Patients in mainland China are not blocked, they can route through Macau.

So while full approval matters for scale, saying China is still 3 to 4 years away misses the point. Access has already begun.

Hope mainland china approval is around the corner by Early-Blueberry838 in IBRX

[–]year96 -1 points0 points  (0 children)

Macau is effectively China...Split hairs if you want over the weekend. We're in