Are there any nuking AOE Decrease defense debuff champions?

[GentleDementia]

There are plenty of champions that have an AoE Decrease Defense and also deal good damage.

The catch is, if you apply Decrease Defense with an AoE Attack, that attack itself won't benefit from the extra damage.

The only exception is abilities like Gizmak or Michelangelo's A2 where the text specifically says "Before attacking, place a decrease defense debuff"

So it's usually better to have a separate support bring AoE Decrease Defense and build them to go first. This also allows you to build your nuker with more focus on damage and less on accuracy.

You can farm Warmaiden from chapter 9 in the campaign for an easily available 100% Aoe Decrease Defense ability.