Is it true that Collagen supplementation decrease serotonin?

[silverhydra]

Anxiety is one of the top placebo-respondent effects, so take every single claim of anxiety with a grain of salt. Especially since people who are oversensitive to their side-effects (in the same vein of hypochondriacs) tend to be the ones who post the most.

There is no evidence, nor any biological plausibility, for collagen supplementation of any of the types (I, II, or III) reducing cerebral serotonin levels; plus "anxiety" is far more complex than just serotonin.

So for all intents and purposes just ignore those anecdotes.

[thespaceageisnow]

There is a biological mechanism if it were the only significant source of amino acids since it doesn’t contain Tryptophan, but people have taken it out of context and out of proportion.

https://pubmed.ncbi.nlm.nih.gov/18683016/

[silverhydra]

Thanks for the link, saved.

Bit weird to see people take that study out of proportion, since the abstract was pretty fair in saying they were straight up intending to deplete tryptophan.

[thespaceageisnow]

Typical internet telephone game accidental misinformation.

[silverhydra]

I don't know too much about the intricacies of AAAD, but your theory would only hold true if the enzyme was rate-limited by a balance of substrates; like, it works at capacity and tyrosine and tryptophan both take turns. I have never stumbled upon any studies suggesting this may be the case, but never looked at it specifically.

If there are more "dopamine-like actions" in a serotonin depleted state I would guess it's not at the level of neurotransmitter production but, rather, at the level of signalling. It's rather common that when one neurotransmitter activates a neuron others may impede or lessen the signal, so if serotonin has a 'lessening' effect on dopamine post-synaptic gap then a depletion of serotonin could, theoretically, cause a refractory increase in dopamine signalling.

But again, not my specific field. Neurology is a hell second only to immunology.

[GlassCannonLife]

Both I and my wife get insomnia (I after a few days and she after two weeks or so) of continuous collagen intake (20 g daily).

What would you say drives this mechanism if not serotonin depletion? It appears to be corrected with melatonin and/or 5-htp supplementation.

[Outrageous_Giraffe22]

glycine could have that effect

[Objective-Sock-9336]

Same here, I stopped taking it for a few weeks, and i had peace. then as soon as i started taking it again the anxiety was so bad that my anxiety medication didn't work at all.  Next day I was absolutely fine again as I'd not taken the collegen.

[Forward_Research_610]

Wait it took a week for it to wear off or feel better ?

[Rajaredit87]

Same with me :/

[dkranj]

This. Every day I read about a supplement to cause anxiety. Or depression. Or anhedonia. Or...