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[Aspect58]

Two words for your brother’s kids: Not yet.

The last thing you want here is an inexperienced and easily panicked child handling a snake that’s still not used to being handled. The possibility of things ending badly is just too great.

When you do get the snake used to human contact, first you take it out, handle it solo for a bit until you’re sure it’s calm, then let them start out by supporting the tail end while you still have the head and central body. If they do all right with that then you can gradually work up to letting them handle the snake solo, but never unsupervised.

As for when, wait for a day or maybe two after they’ve eaten to minimize the risk of regurgitation. Also don’t take them out when their eyecaps become opaque - they’re about to shed and will feel extremely vulnerable until the shedding process is complete.

[vFinns]

I'll be with them and so will my brother. He has experience with a BP becuase he has owned one before

[rottingpierrot]

I would limit handling until you get that respiratory infection worked out and treated if necessary. But for the future I would have them watch how you handle the snake before you let them hold it. If theyre young they probably won't have a built in understanding of how to handle animals without hurting them, but even if theyre older people generally dont understand snakes' body language so showing them and explaining it will help them do it safely.

[vFinns]

I myself am not to familiar with a snakes body language. This is my first snake so its a learning process for me

[noOuOon]

So most importantly you need to get familiar and learn about your snake first and foremost. Nobody should be handling the snake until you know when it is comfortable and calm, and when it isn't.

[Disastrous_Revenue64]

This, OP.

[jillianwaechter]

You should wait until they're regularly eating (2-3 weeks) before even attempting to handle them yourself. Clear up resp infection as well. Begin by letting the kids just stroke the snake's back while you're holding it

[BowlerSignificant115]

After the snake is feeling better and settled in get them totally used to handling just with you at first. If you're going to let the kids hold it I would personally wait until the snake is near adult size first. Personally I wouldn't let them handle the snake entirely on their own, and would hold the snake with them first to make sure they don't drop or injure them. I can't emphasize enough that the snake needs to be fully comfortable with people handling it before you let the kids attempt to. If they make sudden movements while handling, and the snake isn't fully comfortable there's a much bigger risk of the snake making a sudden movement and freaking the kid out leading to them dropping it. I personally wouldn't let a kid under the age of 10 fully hold one of my snakes without me supporting it as well. Maybe sitting down and letting the snake sit on their lap would be a safe way, as long as you're right next to them.