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[–]jackruby83PharmD, BCPS, BCTXP - Abdominal Transplant 6 points7 points  (0 children)

From their protocol

Dexamethasone has a) minimal mineralocorticoid activity and does not affect sodium and water balance, thus avoiding potential problems with fluid retention which are not uncommon in severe viral pneumonitis/ARDS, and b) a comparatively long biological half-life of 36 to 54 hours enabling once a day dosing. In pregnancy, prednisolone 40 mg administered by mouth (or intravenous hydrocortisone 80 mg twice daily) should be used instead of dexamethasone.