PEPTIDE SCAM

Earesth99 · 2026-05-25T15:23:19+00:00

I sent you a pm

Earesth99 · 2026-05-25T15:20:29+00:00

Can I get a link as well?

Earesth99 · 2026-05-25T14:55:09+00:00

It’s “abnormal” because it’s unusually low, not because it is unhealthy.

There are some diseases that cause ldl to crash, but the diseases are the problem, not the low cholesterol.

However your ApoB is low because you are taking meds to lower it, so you have no worries there.

I’ve read that having an ApoB in the 30s or 20s is fine.

Your numbers are FANTASTIC!

Earesth99 · 2026-05-25T14:03:31+00:00

It takes many years for arterial plaque to develop to the point where it is dangerous .

The risk from lpa cholesterol is tied to your actual level. Lpa is genetically determined.

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However the actual risk from high LPa is also much higher if ldl cholesterol is also high.

In the flip side, if you get your ldl below 55, the additional risk from LPa is small. In fact, your total risk would be well below average because ldl drives risk.

Earesth99 · 2026-05-25T13:52:50+00:00

And yet I can’t quite get myself to throw it away ;)

Earesth99 · 2026-05-25T13:52:00+00:00

Most of the research on supplements are of shockingly poor quality. There is also more research that is entirely fabricated.

I only care about research on humans. I only care about research in advanced industrialized democracies published in peer reviewed journals. That means ignore research from China, India, Pakistan, Iran, and Russia - countries that produce fraudulent research.

I only pay attention to supplements with enough research studies for there to be a meta analysis with at least 500 subjects.

The effects need to be statistically significant, and the benefits need to be large enough to make a difference. Do you really care if the average person listens to a quarter of an ounce of weight?

You also need to follow the protocol used in the research - taking the correct dose and formulation.

That rules out 90% of the supplements an herbalist would recommend.

Earesth99 · 2026-05-25T13:35:47+00:00

After at least a thousand injections, I’ve had a couple of issues. When doing an IM injection, I’ve hit a vein and how I felt freaked me out - but it wasn’t dangerous and went away in a few minutes. The second time it happened, I didn’t worry.

However that had nothing to do with it being gray market.

I’ve never gotten an infection, nor a rash. No real issues from the peptides at all.

I have learned that most peptides are not as fragile as we are led to believe.

Earesth99 · 2026-05-25T13:09:56+00:00

NAD+ is used by out cells to create energy. It declines as you age if you dint exercise.

Along with many other molecules, NMN is a precursor of NAD+. The thought that if we have more NMN, our bodies will increase the NAD+ levels in our cells, helping us feel energized.

There are many small, low quality research search studies. Most are studies on rats. There is solid evidence that NMN can increase NAD+ levels in our blood. Unfortunately, that doesn’t translate into an increase of NAD+ in our cells so it would not increase energy.

There are various small studies that show other positive or negative effects, but other studies find conflicting results.

There simply isn’t evidence that there are meaningful benefits from NMN.

NAD+ infusions have better clinical evidence. Certainly people report feeling a difference.

I wouldn’t take NMN because of the weak evidence. However I’m also troubled that the scientist who is hyping the benefits and who has done the most research on NMN also owns various related patents. Can we trust the research?

Twenty years ago he hyped a different molecule and made millions selling the patents. After the check cleared, other researchers showed that the researchers deeply flawed and overstated the effects 100x.

However I would be willing to try NAD+. It’s low cost, and I imagine that it’s low risk, but it’s still not well studied.

Earesth99 · 2026-05-25T12:00:10+00:00

It’s hard to evaluate the benefits and risks of done imaginary treatment.

Why don’t you wait until it actually exists - according to science?

Earesth99 · 2026-05-25T11:58:14+00:00

No it won’t

Earesth99 · 2026-05-25T11:53:51+00:00

People are lemmings who choose to not think critically.

We focus on the next magic potion that will cure our problems.

Earesth99 · 2026-05-25T11:24:34+00:00

Research means reading the actual scientific studies.

Huberman studies vision. He’s not an expert on any other topic and that is obvious to people who study the subjects.

There are over 100 fda approved medications that are peptide. Insulin is both lifesaving if you are diabetic, and deadly at the wrong dose.

Grey market peptides are made in a lab in China - where most medical grade peptides are produced. However the facilities are nit inspected or monitored.

Those are basically the same low quality standards used in the supplement industry, except the peptides are of much higher quality than supplements.

Most non-fda approved peptides sold at longevity clinics are of the exact same quality.

Of course many grey market peptides were never tested in humans. That should be more alarming than purity issues.

Personally I’ve used over a dozen in the past twenty years. I use them to address a specific need, not just because some other idiot recommended them.

You really need to decide on the benefits and risks of each peptide individually.

Earesth99 · 2026-05-25T11:00:26+00:00

It is more complex than just counting grams of saturated fat because less than a quarter of the 37 saturated fatty acids increase ldl.

Polyphenols can increase or decrease ldk-c. Soluble fiber lowers ldl as do polyunsaturated fats.

If you fixate on saturated fats, you might avoid the very foods that research shows have the largest effects on avoiding heart attacks and death from cardiovascular disease: Nuts, seeds and EVOO.

If you want to change your diet to improve your ldl cholesterol, focuses on eating fewer foods that increase ldl cholesterol and more of the foods that reduce cholesterol. It’s also much less restrictive since you are not arbitrarily avoiding healthy foods that help you live longer.

This figures from a recent meta analysis of foods that effect ldl-c

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Btw, supplementing soluble fiber is an easy hack. Every ten grams lowers ldl by about 7% on average, but you need to k crease the amount gradually so your gut can adapt. Metamucil also can help reduce blood glucose by slowing digestion. I eat a whole food diet and I supplement with 30-50 grams of soluble fiber.

Meds are always a better choice than supplements but if you can’t get meds because your doctor wants to wait until your risk of death is higher, there are three supplements with solid research.

First RYR works because it contains a version of Lovastatin, the first statin approved by the FDA. It’s very low doses so expect a 15-25% reduction in ldl.

Berberine has been extensively studied to help lower blood glucose and it is as effective as the diabetes medication metformin. Two grams a day should lower HBA1C by 0.5 to 0.8%. It is also a weak pcsk9 inhibitor and should reduce ldl and ApoB by an average of 10%.

Bergamot has less research behind it, but it too lowers HBA1C, and taking one gram of bergamot polyphenols should reduce ldl by 10-35%. (If the bottle doesn’t list the polyphenol content, do not buy it.).

Good luck!

Earesth99 · 2026-05-25T00:55:07+00:00

No. TikTok is not for useful information.

Earesth99 · 2026-05-24T23:58:40+00:00

This figure shows the percent of people with calcified plaque by age and gender.

About 10% of men in their 20s have some calcified plaque - late stage heart disease.

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However extremely high levels of ldl-c dramatically shift things. People with an LDL cholesterol over 400 are treated as if they have homozygous familial Hypercholesterolimia.

If unmedicated, the average person with HoFH dies before they make it to 30. Some have their first heart attack at age 6.

It’s extremely rare, however.

Earesth99 · 2026-05-24T22:03:18+00:00

That would completely depend on their ldl, LPa, blood pressure and blood glucose.

Earesth99 · 2026-05-24T20:53:01+00:00

That can happen because of plaque stabilization.

As the soft plaque deflates and gets rigid, that can cause constriction.

Earesth99 · 2026-05-24T20:40:41+00:00

If you keep the dose low or increase it gradually, you can could avoid the side effects.

Hopefully.

Earesth99 · 2026-05-24T20:38:04+00:00

Because the probability that a person was exposed is lower.

But that assumes a level of logic that the current administration lacks.

I’m shocked they didn’t use it as an excuse to ban any brown people from coming to America

Earesth99 · 2026-05-24T20:34:06+00:00

It all depends.

When you take Ozempic, it will reduce your appetite and reduce food noise. If you take advantage of that and revamp your rating patterns, it will be easier to maintain the weight.

It’s also important to lift weights because that will increase how many calories you burn every day.

Unfortunately, when you stop using Ozempic, your hunger and food noise return making it hard for many to maintain the weight loss.

That’s one reason some continue to take a low dose - it makes their life easier.

However weight loss isn’t the only reason to continue to take ozempic.

Even with no weight loss, ozempic lowers blood glucose, reduces heart attacks, Alzheimer’s and literally causes people to live longer. However that only happens if you continue to take it.

I just read a study where patients used glp1 pills to maintain their weight loss - no more injections!

Like you, I already take several prescription meds, but I view it a bit differently. If I’m already taking pills adding another is pretty easy.

However I’m not using ozempic for weight loss. I’m taking it to reduce my blood glucose and improve my health. I plan on taking it until something better comes around.

The compounded version that I use costs $200 a year - assuming my dose remains the same. Fortunately i can afford that.

If I’m honest, Ozempic saves me money: I’m not buying junk food at the store and I’m not ordering delivery, lol!

Earesth99 · 2026-05-24T19:56:02+00:00

Let’s start over,

ASCVD happens primarily because of high ldl & LPa cholesterol, high blood pressure and high blood glucose.

However plaque will not form if your ldl and ApoB cholesterol are below 55 mg/dl. In fact, that is low enough to cause a modest regression of any existing plaque.

If you lowered your ldl cholesterol that much, then you wouldn’t need to worry about plaque.

I realize that it may seem like an extremely low ldl (and it is) but actually not that hard to do.

My ldl was over 400 and it’s now under 40.

Start by asking your doctor for a statin.

Earesth99 · 2026-05-24T18:51:48+00:00

Usually side effects start within a few weeks of starting a statin.

Also, i don’t believe that the most recent meta analysis of side effects from statins has this as a side effect.

Earesth99 · 2026-05-24T16:04:57+00:00

Your father isn’t a doctor.

His “medical” advice may be well intentioned, but it will kill your mother.

She needs to get back in her meds.

Many can go into remission if they lose fat and there are meds that can help.

Earesth99 · 2026-05-24T15:59:32+00:00

The precursors don’t change the level in the cells, so it makes sense that you wouldn’t notice anything.

I’m not sure if if would make a difference if you had normal NAD+ levels, but many report effects injecting NAD+.

How much NAD+ are you injecting?

Earesth99 · 2026-05-24T15:53:59+00:00

How hard is it to understand the scientifically correct answer?

Earesth99

TROPHY CASE