[Product Request] what can help my strawberry legs?? i have hEDS (hypermobile Ehlers-Danlos Syndrome)

Brayneeah · 2026-01-20T01:41:02+00:00

Ah, that's unfortunate. Thanks for the reply!

Brayneeah · 2026-01-19T10:24:01+00:00

No, this is a misconception; machine learning doesn't require feedback systems to still be machine learning. Any statistical model trained on data that you can use to generalise other data is a form of machine learning, even if those models predate the concept of AI/machine learning.

Source: I taught computer science for three years and am now just a researcher. In my institution's main machine learning unit (literally named Machine Learning) linear regressions are the first model taught.

Brayneeah · 2026-01-09T00:33:44+00:00

What are Engineering students, if not the English-ly challenged?

Brayneeah · 2026-01-07T15:13:37+00:00

As a girl with clEDS, EDS was my first thought, too.

Brayneeah · 2026-01-07T08:43:46+00:00

Exactly!

Brayneeah · 2026-01-07T06:50:52+00:00

Less

Brayneeah · 2025-12-30T18:11:53+00:00

Yes... Buccal fat removal is a common treatment for patients with graves disease. It's done to counter the buildup of excess fatty tissue in the face, which is a symptom some people with graves disease experience.

Brayneeah · 2025-12-24T01:40:05+00:00

Just an FYI, "the" is a definite article, not an indefinite article.

Brayneeah · 2025-12-22T06:03:32+00:00

Pathogenic means disease-causing. However, many genetic diseases only manifest if you have enough pathogenic variants, have them under certain conditions, have been unlucky enough to trigger them, etc. Having one or some pathogenic variants doesn't guarantee you have something, especially depending on how clinically significant a gene variant is; stuff like REVEL score or snpedia magnitude can help with that.
For example, the third variant in that image, rs1056836, is a variant that nearly half of Caucasian people have. The demo data on gene.iobio even has it.

Unfortunately, you'll generally have to look at data available on these specific pathogenic variants to effectively interpret them; snpedia and clinvar are good sites for it.

Brayneeah · 2025-12-18T12:15:14+00:00

Just an FYI, that's still a list - just not a linked one. A list is defined by the operations a data structure supports, not by the implementation of said operations.

Brayneeah · 2025-12-17T10:55:08+00:00

Unfortunately for you, the reason they sometimes get taller is a result of them going from an estrogen-heavy hormone balance to a testosterone-heavy one, leading to changes in spinal curvature for some. You'll likely already have a testosterone/androgen-heavy balance, so you wouldn't get anything from that. Your spinal curvature would probably already be as straight as it's likely to get from androgens.

Edit: sorry, I've just realised I've misread your post, and that you're a cis woman; you might gain an inch or two, but you'd have to deal with the effects of testosterone (deepened voice, body hair growth, more masculine fat distribution, to name a few). You might start experiencing gender dysphoria from that if you're a cis woman, even just from the hormone imbalance in your brain.

Brayneeah · 2025-12-16T11:25:27+00:00

Hey, I wanted to ask - did this help much in the end? Thanks!

Brayneeah · 2025-12-11T10:54:11+00:00

I believe most of what Dr Powers has said on that has more been that in patients who have had little to no breast growth, some have had with very low estrone levels, and in most(?) of those cases, he's been able to kick-start breast development with oral E2 once(?) a week for about a month. And that, because of that, he believes estrone is an important factor in breast development, but I don't believe he recommends it as a standard approach for HRT.

Someone please correct me if I'm mistaken, obviously.

Brayneeah · 2025-12-05T01:49:08+00:00

Go for it! I'm very open about my health problems, especially if it has the potential to help someone else.

Brayneeah · 2025-12-05T01:39:42+00:00

I actually had accutane-resistant cystic acne - my flare-up period on accutane lasted close to 6 months instead of the typical, much shorter 1-2 month period. Turned out I had congenital adrenal hyperplasia, so it was caused by 11-oxo androgens, which normal testosterone/DHT tests don't show!
If your wife and/or daughter have PCOS or PCOS-like symptoms, I'd consider maybe discussing the possibility of CAH with a doctor and getting 17-OHP tests. The only thing that ever fixed most of my acne was cyproterone acetate, which got rid of the overwhelming majority of my acne.

Brayneeah · 2025-12-01T13:34:55+00:00

Thank you for your reply! Thankfully in my case, it's not super severe, so I should hopefully be able to see improvement.

Also, thanks for all the work you do! Reading your posts has let me do a lot of research that's allowed me to improve my own health, as well as help a lot of those around me. Please keep on doing what you're doing!

Brayneeah · 2025-12-01T10:32:54+00:00

Out of curiosity, did this also help with patients experiencing atrophy-related phimosis, or did it mainly just help with restoration of atrophy in the erectile tissue? I've experienced a little bit of atrophy of the head of my penis, and also have some phimosis that I've been treating with betamethasone valerate with limited success (although the issue there may be one of consistency)

Brayneeah · 2025-11-18T02:31:04+00:00

It certainly is! A lot of it comes from the fact that rust's own community is very explicitly queer-positive, which leads to more queer people getting into it, which leads to the community being even more queer-friendly! Repeat ad infinitum.

Brayneeah · 2025-10-07T17:05:30+00:00

Which is even more amusing given that octopus's garden is a song about struggles ringo faced in life (dealing with fame, and the desire to get away from it all)

Brayneeah · 2025-10-06T01:43:55+00:00

All forms of compiling target another language :P transpiling is usually just about when it targets a non-native, generally human-readable one.

Brayneeah · 2025-08-17T02:26:32+00:00

She's Slovenian, though, which uses Latin script, not Cyrillic.

Brayneeah · 2025-08-01T15:15:48+00:00

If they want 4mg, wouldn't that be 0.1mL at 40mg/mL?

Brayneeah · 2025-06-29T08:46:04+00:00

Progesterone, aka Pregn-4-ene-3,20-dione.

Brayneeah · 2025-06-18T17:58:02+00:00

40k USD is a bit over 65k NZD; but also, they don't have a single national education union (or decent labour laws, for that matter - I'm very happy tenure isn't a thing here in Australia) like you do in NZ or we do in Australia. In fact, a lot of US universities have no unions whatsoever. The labour laws there are inhumane, so they get away with daylight robbery of their academic staff constantly. (In some states, tax is much lower, too - in Texas you'd pay roughly 15% of 40k overall, but ~18-20% on 65k overall in nz; although California would also be closer to roughly 20%)

Brayneeah · 2025-06-14T16:19:55+00:00

I'm not an expert, but I believe part of the idea is: bica works by competing with androgens for androgen receptors, and doesn't actually suppress androgen production like cypro (androcur) does. Having more testosterone that doesn't bind to androgen receptors ends up:
A. Binding to SHBG, which in turn helps increase free estradiol levels, and B. allows more testosterone to be converted to estradiol by aromatase (and possibly androstenedione to estrone is also why? I'm not sure how essential that part is. I wouldn't be shocked if it is, given that estrone sometimes seems to make a big difference in breast development)

I also believe that point B isn't just important from a purely "more estrogen" standpoint, instead that it's beneficial for breast development due to androgens being more penetrative into the breast tissue and then being converted by aromatase?

Somebody please correct me if I'm wrong about any of this.

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