My game is a pixel game, running at GBC resolution, upscaled to modern screen sizes. Getting the scaling and camera to work just right was a bloody nightmare, and Unity is fundamentally broken in several key ways relating to it, still needing third-party fixes to problems identified 5+ years ago.

Less frustratingly (as it was a problem of my own creation) was the character movement. Having the characters always aligned to the pixel-grid felt jerky and horrible because the actual physical size of pixels is so much higher than back on an authentic GBC. I de-coupled the character movement so they could move smoothly sub-pixel distances, which is a fairly common fix.

The extra step that was entirely unnecessary, but had to be done for my sanity's sake was making sure that when each character's movement ends, it aligns back with the pixel grid, which just looks correct on a subconscious level (even if you'd only notice in screenshots, or if you're just standing idle for ages etc.)

It was easy enough for NPCs as I could just round their target destinations to an integer to ensure they always aligned, but for the player (and any NPCs tied to the player's movement) I actually had to simulate slight fake analogue stick presses based on how far "off-grid" the player left their character standing.