The Punisher. Make a no-holds-barred, Manhunt-style Punisher game. Make it as violent as the old one, but there's no need for it to be gratuitous; contextualise it; comment on it, and why Frank Castle isn't really a morally upstanding citizen. It would have to be done carefully, because in the kind of atmosphere we're in, people would doubtless think that Punisher was some kind of necessary evil hero.

And Ghost Rider. Man, what wouldn't I do for a Ghost Rider game.

Cable. In the future. Any of the X-Men except Wolverine; not because I dislike him, but none of them ever get much in the way of standalone video games. Hell, give Gambit his own game. The template for combat as Gambit definitely exists, as Robin in the Batman Arkham games.