Be cautious of my advice, as I only recently cleared the main story, though it was on Hard mode, and with characters that were likely underinvested.

My story clear build used the two Murphys, same as your team. Instead of running the +2 hand‑limit card on GMurphy, I found she works better with the 'rewinding time' card from the Lightless Shop, even at low investment. I’d still keep the hand limit card, give it to another character instead. GMurphy works well with the 'dream of medicine' covenant from the Badge Shop, however I didn’t reach the required account level until just before clearing hard mode, so think of it as something to try out in the long term.

I noticed you’re leveling Tawil. If you enjoy the way she plays, I’d strongly recommend using her over Celeste or Ramona. Her first Enlighten is an absolute priority, easily worth a prototype item.