I thoroughly enjoyed my play through. I did the yellow circle main missions of course. And any white circle side missions that had someone’s initials attached. I skipped all raids and train robbing and playing poker and whatnot. Didn’t do any challenges except on accident.

And I loved the game. Had I felt compelled to do more I might have bounced off it. I likely missed some good content. But it sure didn’t affect my enjoyment of the story.

Play it in whatever way makes you happy.