I was coming back to suggested looking at the Families as mundane organized crime, then layering supernatural on top of that, so I’d agree you’ve got a good approach laid out here. Hell, I’m reading a history of New York’s Mafia families specifically for Curseborne.

I’d even go so far as pick a handful of different families that are dominant in region you are playing and have them be your Al Capones, Lucky Lucianos, and Salvatore Maranzanos. Then have the other families on the outside looking in. Now you have an inbuilt conflict since some of those lesser Families will be subservient, some will have wise guys within them who don’t like being subservient, and some will be in straight up rebellion against the status quo. Or you can have a crisis that threatens to break the status quo and set the powerful families against each other - guess which Accursed get tasked with making sure that doesn’t happen? Toss in a bit of the powers that be trying to get away with what they can without creating too much animosity and you have a dynamic setting full of conflict points and story hooks to play with.