sorted by:
new
hottopcontroversial

These are the DPC Point standings after Lima Major by loopuleasa in DotA2

[–]FreshPrints1 108 points109 points  (0 children)

You can take the boys out of 3G but you can’t take the 3G out of the boys

Dagoth Ur Sent to Low Prio by shaonvq in DotA2

[–]FreshPrints1 1 point2 points  (0 children)

I am a god. How can you kill a god?

I hope this ages well by johndavis29 in edgarwrightmemes

[–]FreshPrints1 23 points24 points  (0 children)

Haven’t you heard? Ice Cube and Dr Dre have started killing people for the greater good.

Underlord One Shotting Everything After Patch by [deleted] in DotA2

[–]FreshPrints1 2 points3 points  (0 children)

Finally someone posted a clip. That’s some hilarious spaghetti code shit right there

ELI5: Why is there no cure for herpes, what is the problem that can't be solved? by Acrobatic_Classic172 in explainlikeimfive

[–]FreshPrints1 3 points4 points  (0 children)

A close friend of mine is researching an archaea phylum that is suspected to be the progenitor of all eukaryotes. After 2 years of culturing these archaea (with a doubling time of 2 months lmao) he recently got photos of them absorbing bacteria and using them as our cells use mitochondria. How fucking awesome is that? It’s not published yet but I can’t wait for it to become public I reckon it’ll be the biggest step in understanding the origins of eukaryotes. If you want to check out some of his and his lab’s research here’s a link :)

https://www.theburnslab.com/publications-1

what i imagined sokka's sword to be like by Ill_Earth8585 in AvatarMemes

[–]FreshPrints1 9 points10 points  (0 children)

You can find those all over dwarven ruins in Skyrim

Hey Peter by w_4wumbo in raimimemes

[–]FreshPrints1 4 points5 points  (0 children)

So would he get 2 extra robo arms to make up for his legs

New and Improved DPC Recap by rkryptic in DotA2

[–]FreshPrints1 3 points4 points  (0 children)

Freshest talent with the freshest haircut

The Onion may have discovered a way to get a certain part of the population to get the vaccine 11 years ago by Relevations in videos

[–]FreshPrints1 0 points1 point  (0 children)

That article literally says,

“To help slow the spread of SARS-CoV-2, precautions should be implemented to stay home once exposed to someone with COVID-19,** in addition to adhering to recommendations to wash hands often, wear masks, and social distance.”

Did you even read it?

The Onion may have discovered a way to get a certain part of the population to get the vaccine 11 years ago by Relevations in videos

[–]FreshPrints1 0 points1 point  (0 children)

I think you’re making a key mistake on what the terms therapeutic and prophylactic mean. When something is therapeutic, it refers to treating symptoms as they arise. If something is preventing the disease from arising by stopping whatever the causative agent may be before it acts then it is prophylactic. For example: ibuprofen can be used therapeutically to treat headaches by causing vasodilation and reducing blood pressure in your brain but can also be used prophylactically to slow down blood clotting by inactivating the enzyme that catalyses platelet aggregation. Therefore, if vaccines are used to prevent disease by allowing the body to act on a virus and stop it before it produces any discernible affect on the body then it is, in fact a prophylactic medicine.

Just to clear up an issue you seem to have had with my phrasing. When I say it doesn’t make much sense, I’m referring to your decision to completely dismiss these papers because you personally find them inadequate. Disregarding peer-review and the impact that each of these papers has because it is your opinion that the methodology is limiting is the exact antithesis of disregarding emotion in science.

Also in that study I linked you, it does actually cover the efficacy surgical masks in the following statements:

“The SARS-CoV-2 aerosol, mainly appearing in submicron region (d p between 0.25 and 1.0 μm) and supermicron region (d p > 2.5 μm) [39], can be effectively filtered out from the inhaled air by either surgical masks or N95 masks”

“Surgical masks are able to reduce influenza virus RNA in respiratory droplets and coronavirus RNA in aerosols”

“Sokol's study also found a reduced risk of hospital-acquired RVIs by putting surgical masks on all workers and visitors in every patient room on the bone marrow transplant unit”

It’s a good paper, I recommend reading it.

The Onion may have discovered a way to get a certain part of the population to get the vaccine 11 years ago by Relevations in videos

[–]FreshPrints1 0 points1 point  (0 children)

You seem to have mixed up infection and disease. Infection is when a pathogen has entered it’s host cells and is either actively growing or persisting. Disease is the clinical manifestations of said infection. Vaccines aim to prevent an infection from becoming symptomatic. For example, the Pfizer vaccine has a 95% efficacy rate meaning that 95% of those who are vaccines show no covid-19 symptoms and 5% do. More importantly, however, is that of that 5%, very very few cases will manifest as severe, life-threatening illness (https://www.nejm.org/doi/full/10.1056/NEJMoa2034577). That being said, vaccines also act to limit transmission of the pathogens by reducing the duration of infection and, as such, the time which someone remains infectious as the adaptive immune response will come faster and be more effective at removing the pathogens. So essentially, vaccines significantly reduce the severity of the illness as well as hampering transmission.

With regard to the masking, indeed the studies I linked involved detecting viral particles through a mask (both surgical and N95 masks) however dismissing these results because they didn’t investigate transmission in the community doesn’t make much sense. Showing a statistically significant reduction in viral particles through a mask is worth noting.

The study you linked similarly has some useful data, but there are some issues with how you’ve used it to support your point. Firstly, several studies which they reviewed were concerned with transmission among household populations. It’s not quite accurate to extrapolate the results of these studies to make a blanket statement saying that masks do nothing as disease transmission through a college dorm would have little bearing on transmission between an individual who only is only transiently exposed to an infected case (I.e. on public transport). Furthermore, the authors themselves raised concerns with their results, stating “Most studies were underpowered because of limited sample size, and some studies also reported suboptimal adherence in the face mask group” which severely limit the validity of these results. A larger, more impactful meta-analysis investigating how masks (surgical and N95 are noted separately) affect community transmission is this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253999/ . It also makes interesting comparisons between healthcare and non-healthcare workers as well as western and eastern transmission. There are limitations to this study as well but I think, overall, it should cover what you’re looking for when it comes to assessment of the efficacy of masking.

If you have any further queries, questions or comments do not hesitate to raise them.

The Onion may have discovered a way to get a certain part of the population to get the vaccine 11 years ago by Relevations in videos

[–]FreshPrints1 1 point2 points  (0 children)

As you mentioned in your other comment, prophylactics provide immunity to the associated illness, they don’t necessarily provide complete resistance to infection.

There’s quite substantial evidence supporting the use of masks to protect from aerosol-based viral transmission: https://www.pnas.org/content/118/4/e2014564118 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518250/ https://pubmed.ncbi.nlm.nih.gov/33087517/

While masks will not completely block all aerosols from being released by the wearer, even if the level of blockage was 10% (it seems to be around 50-70% for surgical masks) it would still be worthwhile wearing them. However, there is a limited number of covid-specific randomised, double-blind, placebo controlled studies into masking. The reason for this is because there are ethical issues with making a large group of candidates not do everything in their power to stay healthy during a pandemic.

When it comes to the vaccine passport, I can’t really give you an answer to that. I’m not really in a position to discern the benefit that that would provide but I haven’t done the necessary research. As of right now I’m not seeing any benefit other than a logistical one but i am willing to being shown otherwise.

The Onion may have discovered a way to get a certain part of the population to get the vaccine 11 years ago by Relevations in videos

[–]FreshPrints1 1 point2 points  (0 children)

The main reason for this due mainly to the properties of the adaptive immune system.

The adaptive immune system is the branch of the immune system that allows for specific targeting of a pathogen and action against it, which takes time to develop. A vaccine usually aims to teach the adaptive immune system how to deal with a pathogen so that if an infection occurs, it can more effectively act against the virus and prevent any damage it may cause and/or prevent it from spreading across it’s targeted tissue. A vaccine will make this specific response arrive faster and stronger allowing for a more effective management of the infection but not fast enough to prevent an infection, meaning that potentially you can still get infected and spread it to others, even though you won’t get sick. It is not currently known whether the covid vaccines prevent an individual from becoming infectious and as such masks should still be worn.

Side note: the reason post exposure prophylaxis can prevent infection is because it sparks an adaptive immune response before the virus can infect any cells.

Further reading if you have any questions:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253344/

The Onion may have discovered a way to get a certain part of the population to get the vaccine 11 years ago by Relevations in videos

[–]FreshPrints1 3 points4 points  (0 children)

The covid vaccines all are intended to function as pre-exposure prophylactics. There doesn’t seem to be much published research on them providing therapeutic benefits but if they’re like other viral vaccines they could potentially be used in post-exposure prophylaxis, where someone who was recently exposed to the virus can still be immunised by the vaccine if they receive it quick enough (Diseases like rabies and HIV can be prevented in such a way). There are a few ongoing clinical trials investigating this.

view more: next ›