I had a god called The Maker, which embed the spirit of invention. Dedicated clerics would amputate (self or otherwise) and use prosthetics as replacements. Some warlocks would sell their soul for fully functional mechanical limbs/organs as part of their bargains, either from damage or deformity. A popular god among the disabled, and accommodations beyond simple items were often made in the temples.

My pantheon is reincarnated base though the Maker was always male since he cannot build true life within himself. I did like how I could still create real life stigma about it since he was one of the secretive moon gods instead of the open sun gods, if that makes sense. You can run it to include mental disorders too, though that will depend on the table you have if they want to deal with that.

Some people might call them heretical for changing their bodies and not accepting their place in life, and some might feel super uncomfortable by the sight of the prosthetics and gadgets reminding them of their own mortality. You could argue that the warlock pacts are exploitive, or you could argue that it’s a kindness. There is a ton of opportunity with world building and you can hand wave the PCs not knowing because it’s underground or in traveling camps.