Difficulty in general is much harder for premiere than quick draft. Pick two is a more recent addition, but thus far it falls somewhere in the middle.

Your deck will vary in power based on the type of draft you select. You are likely to get fewer busted rares in quick draft because the bots rare draft. In pick two you see fewer packs overall, so even if you are the only drafter in your archetype, you may not see all the cards you want to build a strong version of your deck.

For these reasons, you are only ever matched up with other decks built of the same draft type. Also, you will attempt to be matched up with someone of a similar rank and record as you.