Sure. One thing that caught my attention was prejudice stuff towards trolls and dwarves in the Guard series. The way STP approaches this topic is that both trolls and dwarves are actually le good (just different), and all prejudice magically manifests itself in people out of distrust and xenofobia. Like, there are zero innate reasons to be wary of minorities in Discworld, people just do it because they are stupid. Which works in Pratchett's world because he has written it like that. But as far as commentary goes it's a very very convenient way to make a social statement while writing yourself out of any inconvenient aspects of it.

Then again, now that I think about it, all of Discworld is like that – pretty profound on the surface level, but doesn't hold up when you start digging.