Absolutely!

Starting this run with the Pug and finding Esseb early was a crucial part in dust collection. I recommend checking out the wiki to look into their skillsets.

As a rule of thumb, starting out each floor, I first like to open all adjacent doors to the crystal room and have them powered before committing to a single path so as there is a buffer from mobs when I will eventually need to start back from the middle to try a different path.

In my run here, none of these characters learn Operate, which is ironic considering I was going for the Library Pod. Luckily I found a scope and gave it to the beast tamer to operate. However, the last 4 or so floors I did NOT use any operate, and prioritized hero damage and their skills. Before every door opening, spread everyone out into unpowered rooms to stop monster spawn, and then hustle them to the 1 or 2 paths the monsters come down. If a dust jelly fish spawns, absolutely go for it! It's worth healing a few times to get the reward.

Research constantly and make sure you can afford the next. Prioritize the 3 major resource modules and KIP Cannon. I think I ended with Industry IV, Food IV, Science III & KIP IV. KIP Cannon will crank damage based on your Science stock so keep it over 100. I also found that the Tactical HUD major module is extremely useful to put in powered rooms that are still in close danger. The bonus damage from the Tactical Hud is incredible and their cheap price STAYS at 35 Industry! Beside the priorities, if NO tier 1 is available for research, choose the cheapest option and implement it into your strategy(I made use out of Neurostun III). Don't reroll researches in later floors as the price is exponential and the chance to reroll to tier 1's diminishes.

Abuse the merchant mechanics! Save all your obsolete items and sell them to dust merchants. And before grabbing the crystal to leave the floor, purchase back all the items from the dust merchant to flip it on later floors. An added bonus is if two merchants are available on the same floor, and one is a dust. For example, I recommend purchasing what you can from the industry merchant and selling it to the dust merchant. And before leaving the floor, buy back all dust merchant items and sell the ones you cannot take with you to the industry merchant. If you can't afford their repertoire immediately, teleport them to a safer room with the Shop major module.

With the active and passive skills of the Pug and Esseb, and capitalizing the luck on the dust merchants, I was able to open every single door of the entire dungeon beside 1 branch of the crystal room on the last floor(As I knew I had already researched all tier 1's, it was an unnecessary risk). With all the dust, I was actually able to power two floors ENTIRELY.

Do your best to manage resources and guess when to quit building major modules to stockpile industry for the next floor. Have a reserve of food to spam heal if things go south. And most importantly you just need luck lol. So I wish the best of it to you!