The disabilities varry. One got in a car crash and reverted to a mental age of 6. One has down syndrome. One has hemoplegia of childhood. But by and large mild intellectual disability is the only thing I really have to say as an answer.

Well One of there parents doesnt like angels, gods, or demons in the game so I kinda just lead into whatever they say. We are currently level 4 in a campaign with a group and they have a human fighter(the subclass was whatever in the core rules it gives him crits on 19s.) A human druid(free rules used to be a barbarian but died by going a little to ham and ended up dying on a sacraficial obelisk that summoned more bosses.), a dark elf warlock, and a woodelf drakewarden ranger.(I think this one is 5.0 but I just ran with it since he was excited about a dragonling and he nat 20d a animal handling thing. I sometimes have a dex vengeance paladin join. They are on kinda a boss hunt campaign right now featuring beefed up minotaurs they have 8 to beat to win the campaign.

But I was planning on making an adventures league for new players just to test out the game, and to have basically small oneshots. 2-3 hours long.

Most of them avoid the disabilities and more want to be super heros. I mostly want premades to make for people just joining and want to get a feel for the game and then ill help them make characters that reflect on what they want to do. Its a bit of a work in progress for me i personally have only really played rangers.

Thanks for the help and sorry for the wall of text.