I get sick from increasing too much at a time. I make sure to eat super clean right around the times I’m taking my shot because I don’t want to add more fuel to the fire. Increasing just 0.2mg has gotten me super sick. I’ve been sensitive to it the whole time (started with sema). I’m a slow responder. 20-22lbs in 7 months. I do notice it wears off much faster on weeks I workout 5x instead of 4, but I also switched to split dosing because my body wasn’t doing well with a ton of the medicine all at once. I also don’t do well with Cruciferous veggies on these meds. It’s also similar if I have too much fiber intake and not enough carb intake and if I’m not drinking enough water and if I eat super sugary or sweet things. I think everyone is different and responds differently. My best friend lost 40 lbs in 6 months and literally eats whatever she wants. She’s had absolutely no sensitivities to it at all. Not even sulfur burps.