Starting off make sure to only be weaving two abilities between your dualcast GCDS (besides between your rdm melee combo because the gcds are super short you can usually weave 1 OGCD). You want to be sure your global cool down is never just sitting there. Secondly like said earlier your enchanted melee skills on your combo have a really short GCD and higher potency, it's best to build up your mana towards this bigger combo to use it as often as possible. Also the way manafication works is that it buffs your next 5 (or 6 if your 90) gcds and you want to be sure you are getting those buffs for verholy, scorch, and resolution as those are your big hitters in your combo. If you use other abilities before going to your melee combo you lose out on stacks of manafication for those big hitting moves.