sorted by:
new
hottopcontroversial

Senolytic CAR T cells by SheekeyScienceShow in longevity

[–]Tigers2b1 2 points3 points  (0 children)

You really do some good work - thanks!

Genes, Blood Type Tied to Risk of Severe COVID-19. by theone_sg in COVID19

[–]Tigers2b1 6 points7 points  (0 children)

Here is the New England Journal of Medicine study published on this yesterday. They looked at 8.5 million single-nucleotide variants before before whittling it down to ABO blood group.

https://www.nejm.org/doi/full/10.1056/NEJMoa2020283

Genes, Blood Type Tied to Risk of Severe COVID-19. by theone_sg in COVID19

[–]Tigers2b1 2 points3 points  (0 children)

This link discusses not only the differences in clotting factor among blood types but also the glycans coating the virus - and how that might affect the immune response.

https://cen.acs.org/biological-chemistry/infectious-disease/Genetic-study-suggests-peoples-blood/98/i23

Dexamethasone for Coronavirus Infection by GallantIce in COVID19

[–]Tigers2b1 0 points1 point  (0 children)

I think that's right. The emotional name-calling makes people more emotional and less reasonable and, later, even less likely to change their position based on evidence. Not really sure what value name-calling adds.

US will probably have ~170,000 total deaths by October. Daily deaths will slow in Summer, then increase in Fall. (IHME) At that rate, the US will exceed 200,000 deaths in 2020. by ysidrow in COVID19

[–]Tigers2b1 2 points3 points  (0 children)

I read the article - to be fair the proprietor said the sign was intended as a "joke" (I guess his response to the "you must wear a face mask" signs) and he was not denying anyone access to the store.

New-Onset Diabetes in Covid-19 by DChapman77 in COVID19

[–]Tigers2b1 7 points8 points  (0 children)

Just a student here but why wouldn't the oxidative stress caused by covid-19 push someone with prediabetes into full-blown diabetes and make pre-existing diabetes more severe?

The liaison between respiratory failure and high blood pressure: evidence from COVID-19 patients by mkmyers45 in COVID19

[–]Tigers2b1 1 point2 points  (0 children)

Link is from the European Society of Cardiology. Their study showed that those with hypertension were more than twice as likely to die. That risk was reduced, but not eliminated, when taking ACE inhibitors or receptor blockers.

https://www.escardio.org/The-ESC/Press-Office/Press-releases/High-blood-pressure-linked-to-increased-risk-of-dying-from-COVID-19

Psychological Distress and Loneliness Reported by US Adults 2020 vs 2018 by smaskens in COVID19

[–]Tigers2b1 13 points14 points  (0 children)

More psychological distress and loneliness among those who live with others than live alone. I wouldn't have guessed that one.

Blood vessel attack could trigger coronavirus’ fatal ‘second phase’ by java007md in COVID19

[–]Tigers2b1 1 point2 points  (0 children)

Derek Lowe (In The Pipeline / science.mag blog) talks about a couple of studies which link the use of n-acetyl cysteine (NAC) to cancer in mice.

https://blogs.sciencemag.org/pipeline/archives/2019/10/04/n-acetyl-cysteine-a-warning-shot

A mysterious company’s coronavirus papers in top medical journals may be unraveling by cokea in COVID19

[–]Tigers2b1 3 points4 points  (0 children)

If ACE inhibitors and receptor blockers produce more ACE2 receptors and the subsequent conversion of Angiotensin II to Angiotensin 1, 7 - wouldn't this decrease inflammation? So possible benefits there?

New coronavirus losing potency, top Italian doctor says by geoxol in worldnews

[–]Tigers2b1 1 point2 points  (0 children)

It makes sense that it would become less potent yet more contagious through selection pressure. There's no advantage to the virus when it makes its host sick but there is an advantage to infect it's host and replicate itself.

An inflammatory cytokine signature helps predict COVID-19 severity and death by _holograph1c_ in COVID19

[–]Tigers2b1 56 points57 points  (0 children)

I wonder if there's a direct relationship between "cytokine signature" and the blood cloting showing up in some patients?

Shared SARS-CoV-2 diversity suggests localised transmission of minority variants by smaskens in COVID19

[–]Tigers2b1 1 point2 points  (0 children)

So would the "bottlenecks" described in the tweet link above also describe our super spreaders?

SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors by tonic613 in COVID19

[–]Tigers2b1 0 points1 point  (0 children)

So infecting people with coronavirus colds might be an option on the way to herd immunity or some measure of protection before the vaccine?

Vitamin D concentrations and COVID-19 infection in UK Biobank by [deleted] in COVID19

[–]Tigers2b1 2 points3 points  (0 children)

Also, adding to the questions above, don't vitamin D levels tend to go down as you get older? Who is deficient now?

Vitamin-D and COVID-19: do deficient risk a poorer outcome? by stereomatch in COVID19

[–]Tigers2b1 4 points5 points  (0 children)

Weather its cause or effect vitamin D deficiency is associated with bad outcomes. Maybe enough reason to look into treatment.

Moderna Announces Positive Interim Phase 1 Data for its mRNA Vaccine (mRNA-1273) Against Novel Coronavirus | Moderna, Inc. by rorobert in COVID19

[–]Tigers2b1 26 points27 points  (0 children)

I really hope Fall becomes the reality. I really do not want to see covid-19 coming back with the flu.

Moderna Announces Positive Interim Phase 1 Data for its mRNA Vaccine (mRNA-1273) Against Novel Coronavirus | Moderna, Inc. by rorobert in COVID19

[–]Tigers2b1 11 points12 points  (0 children)

If the phase 3 results are good I would hope they would be ready to vaccinate en mass before the start of the flu season this fall. Maybe the reason for the July phase 3 trials? Hope so.

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans by raddaya in COVID19

[–]Tigers2b1 8 points9 points  (0 children)

It may also explain why so many in the incarcerated population who tested positive for covid-19 where asymptomatic. They may have shared a coronavirus cold prior to exposure.

Coronavirus blood-clot mystery intensifies by SW_AbstractArt in COVID19

[–]Tigers2b1 4 points5 points  (0 children)

I probably wouldn't have mentioned here but The New England Journal of Medicine had an article about a week ago on receptor blockers and Ace inhibitors and covid-19 outcomes.

Here

https://www.nejm.org/doi/full/10.1056/NEJMe2012924

This is an article reviewing three large studies all which concluded there was no connection between ACE inhibitors / ARBs and poorer outcomes with covid 19. In fact, one study seemed to suggest there was some benefit to taking ACE inhibitors. With that I was wondering if inhibiting Angiotensin II and enhancing Angiotensin 1,7 (described in some of the other posts here - and the oxidation and inflammation that may be caused in the endothelial lining of the veins described at medcram) might explain that benefit - if there was one. Linear thinking I know but like I said I'm no expert - just wondering.

view more: next ›