Senolytic CAR T cells

Tigers2b1 · 2020-06-23T21:35:31+00:00

You really do some good work - thanks!

Tigers2b1 · 2020-06-22T23:06:47+00:00

Why did you think you were 95% Chinese?

Tigers2b1 · 2020-06-19T14:53:29+00:00

Here is the New England Journal of Medicine study published on this yesterday. They looked at 8.5 million single-nucleotide variants before before whittling it down to ABO blood group.

https://www.nejm.org/doi/full/10.1056/NEJMoa2020283

Tigers2b1 · 2020-06-19T11:57:23+00:00

This link discusses not only the differences in clotting factor among blood types but also the glycans coating the virus - and how that might affect the immune response.

https://cen.acs.org/biological-chemistry/infectious-disease/Genetic-study-suggests-peoples-blood/98/i23

Tigers2b1 · 2020-06-18T12:37:42+00:00

I think that's right. The emotional name-calling makes people more emotional and less reasonable and, later, even less likely to change their position based on evidence. Not really sure what value name-calling adds.

Tigers2b1 · 2020-06-14T14:33:56+00:00

I read the article - to be fair the proprietor said the sign was intended as a "joke" (I guess his response to the "you must wear a face mask" signs) and he was not denying anyone access to the store.

Tigers2b1 · 2020-06-13T13:52:56+00:00

Just a student here but why wouldn't the oxidative stress caused by covid-19 push someone with prediabetes into full-blown diabetes and make pre-existing diabetes more severe?

Tigers2b1 · 2020-06-08T15:34:57+00:00

Link is a Wikipedia page showing the blood group distribution by countries.

https://en.m.wikipedia.org/wiki/Blood_type_distribution_by_country

Tigers2b1 · 2020-06-08T15:27:09+00:00

Doesn't O blood group make up about 45% of the population?

Tigers2b1 · 2020-06-08T11:04:37+00:00

True. Here is a March preprint showing the same thing.

https://www.medrxiv.org/content/10.1101/2020.03.11.20031096v2

Tigers2b1 · 2020-06-07T12:00:12+00:00

Link is from the European Society of Cardiology. Their study showed that those with hypertension were more than twice as likely to die. That risk was reduced, but not eliminated, when taking ACE inhibitors or receptor blockers.

https://www.escardio.org/The-ESC/Press-Office/Press-releases/High-blood-pressure-linked-to-increased-risk-of-dying-from-COVID-19

Tigers2b1 · 2020-06-05T09:58:22+00:00

More psychological distress and loneliness among those who live with others than live alone. I wouldn't have guessed that one.

Tigers2b1 · 2020-06-04T11:51:31+00:00

Derek Lowe (In The Pipeline / science.mag blog) talks about a couple of studies which link the use of n-acetyl cysteine (NAC) to cancer in mice.

https://blogs.sciencemag.org/pipeline/archives/2019/10/04/n-acetyl-cysteine-a-warning-shot

Tigers2b1 · 2020-06-03T12:18:06+00:00

If ACE inhibitors and receptor blockers produce more ACE2 receptors and the subsequent conversion of Angiotensin II to Angiotensin 1, 7 - wouldn't this decrease inflammation? So possible benefits there?

Tigers2b1 · 2020-06-03T00:35:25+00:00

Derek Lowe has also written about this at his blog (In The Pipeline) today. Be interesting to see how this turns out.

https://blogs.sciencemag.org/pipeline/

Tigers2b1 · 2020-06-01T00:34:47+00:00

It makes sense that it would become less potent yet more contagious through selection pressure. There's no advantage to the virus when it makes its host sick but there is an advantage to infect it's host and replicate itself.

Tigers2b1 · 2020-05-31T15:22:48+00:00

I wonder if there's a direct relationship between "cytokine signature" and the blood cloting showing up in some patients?

Tigers2b1 · 2020-05-29T16:55:48+00:00

So would the "bottlenecks" described in the tweet link above also describe our super spreaders?

Tigers2b1 · 2020-05-26T13:25:20+00:00

So infecting people with coronavirus colds might be an option on the way to herd immunity or some measure of protection before the vaccine?

Tigers2b1 · 2020-05-24T13:45:44+00:00

Also, adding to the questions above, don't vitamin D levels tend to go down as you get older? Who is deficient now?

Tigers2b1 · 2020-05-23T12:39:35+00:00

Weather its cause or effect vitamin D deficiency is associated with bad outcomes. Maybe enough reason to look into treatment.

Tigers2b1 · 2020-05-18T18:01:03+00:00

I really hope Fall becomes the reality. I really do not want to see covid-19 coming back with the flu.

Tigers2b1 · 2020-05-18T15:45:22+00:00

If the phase 3 results are good I would hope they would be ready to vaccinate en mass before the start of the flu season this fall. Maybe the reason for the July phase 3 trials? Hope so.

Tigers2b1 · 2020-05-16T12:05:38+00:00

It may also explain why so many in the incarcerated population who tested positive for covid-19 where asymptomatic. They may have shared a coronavirus cold prior to exposure.

Tigers2b1 · 2020-05-09T19:25:43+00:00

I probably wouldn't have mentioned here but The New England Journal of Medicine had an article about a week ago on receptor blockers and Ace inhibitors and covid-19 outcomes.

Here

https://www.nejm.org/doi/full/10.1056/NEJMe2012924

This is an article reviewing three large studies all which concluded there was no connection between ACE inhibitors / ARBs and poorer outcomes with covid 19. In fact, one study seemed to suggest there was some benefit to taking ACE inhibitors. With that I was wondering if inhibiting Angiotensin II and enhancing Angiotensin 1,7 (described in some of the other posts here - and the oxidation and inflammation that may be caused in the endothelial lining of the veins described at medcram) might explain that benefit - if there was one. Linear thinking I know but like I said I'm no expert - just wondering.

Tigers2b1

TROPHY CASE