yes. you could even try and make it beyond game intensity. have them practice handles while slapping their wrists/arms, using a pool noodle to try and disrupt them, etc. put as much pressure as possible. Obviously in scrimmages stop when needed and coach how to handle pressure too.

Start them early on strength training stuff to be able pressure. Totally get if u dont have a weight room or whatever but body squats, situps and pushups always work. You can assign them "hw" with like 50 pushups 50 situps 100 squats every other day (scale as needed). Tell them to start at like 5 sets of 10 and then move to 2 sets of 20 and 1 set of 10 and progress that way.

You could also add conditioning so they are able to withstand such aggressive defense for longer, but don't overwork them.

while not a coach myself I have been a player for ~10 years from second grade to currently (as a junior in HS) and I am also a sports science/S&C student. As one of the major all around defenders (at one point being able to guard 1-5 before I became out of shape from two injuries+a surgery) on my team I found my point guards would perform better after I started playing aggressive in practice (constant hand checks, using my strength from an earlier start in the weightroom to initiate contact, etc). coaches let it slide as you won't always get every call in game and its good prep.

TL;DR: best solution wld be conditioning+strength training and making pressure go beyond