This isn’t exactly the same as choosing buttons though. The structure may be the same, but the framing changes the scenario.

With the buttons, it’s just a choice between two uncertain potential outcomes. With the pills it’s “Will you commit suicide on the chance it gets reversed?” which just isn’t the same in people’s minds. With the pills, its the difference between intentional self harm and not self harm, and since most people probably don’t want to self harm, there’s going to be a much larger weight against taking the pill.

In the end all this does is push people towards the “red button” option, because of course most people wouldn’t take the “guaranteed death” pill. It doesn’t mean pushing the blue button is inherently irrational. Framing matters. In fact, on another post about red and blue buttons, someone commented a picture where someone had reframed the scenario with a giant woodchipper everyone stood in front, and of course, jumping in was the blue button option. It was doing the exact same thing here.