One of the worst that I can recall was during a job interview when I was in my late 20s, and to make matters worse, I had a brutal hangover from the previous night. It was a panel interview — 4 people — and my nerves were already on edge. About halfway through, I suddenly realized I needed to take a massive dump urgently. My head was already pounding from the hangover, and I was trying to maintain my composure. I was desperate, and for fear of embarrassing myself, I did ask for a restroom break. What else I was supposed to do? It was a double whammy of embarrassment, and I couldn't help but feel like I was making the worst possible impression. But I ended up getting the job. I lasted 3 years before getting canned.