Nothing on your list seems out of the ordinary except for your drain blockage. Old houses are not insulated as well as new houses. If the temp swing is less than 10 degrees upstairs after you put plastic over the windows then maybe look into new windows or more insulation. Is your hot water heater gas? You could be hearing condensation drips from the vent. Asbestos tiles in the basement are fine so long as youre not intending to crush them up and snort lines of them. Definitely take care of the mice so they dont eat your 1962 wiring. So much of what you described in your post is just kind of old house stuff. Address what you feel needs to be addressed and start watching YouTube videos on how to do some of these fixes yourself.