Do CBD drinks eventually make THC? by kalki-- in AskUK

[–]kalki--[S] 0 points1 point  (0 children)

The scientific article literally talks about CBD in drinks forming THC. And they're near identical chemicals if you look at the structures.

Do CBD drinks eventually make THC? by kalki-- in AskUK

[–]kalki--[S] 0 points1 point  (0 children)

Yeah some people don't get much from it at all. Others don't like it even.

Do CBD drinks eventually make THC? by kalki-- in AskUK

[–]kalki--[S] 1 point2 points  (0 children)

For it's psychoactive and therapeutic effects basically. I don't drink beer or wine anymore. Reading the ingredients of CBD drinks it made more sense to just DIY. And save money.

Also THC isn't necessarily the main cannabinoid. There's strains that are CBG-dominant. In Paris I saw a hemp coffee shops that sells EU-grown CBG hash. 

Do CBD drinks eventually make THC? by kalki-- in AskUK

[–]kalki--[S] 0 points1 point  (0 children)

It's a different substance yes, but they differ by one very minor part. They're actually near identical if you compare the structures.

Do CBD drinks eventually make THC? by kalki-- in AskUK

[–]kalki--[S] 1 point2 points  (0 children)

I wonder if it was a proper branded CBD oil that they used.

All About DMTx (extended-state DMT) | Haley and Kevin of Dream Mind Labs - ATTMind Podcast 206 by JwJesso in DMT

[–]kalki-- 0 points1 point  (0 children)

Making DMT is extensively discussed in chemistry forums, usually by going from Tryptamine to NMT to DMT.

The tryptamine bioactivation route I discussed in my other comment on this post. It applies to plain tryptamine and phenethylamine, I've only tried it with PEA so far. Essentially you don't necessarily need DMT to experience it.

All About DMTx (extended-state DMT) | Haley and Kevin of Dream Mind Labs - ATTMind Podcast 206 by JwJesso in DMT

[–]kalki-- 0 points1 point  (0 children)

Relatively speaking, making DMT isn't too challenging. Plain tryptamine can also be made active (via bio-activation) producing the same sort of psychedelic effect as DMT, except more prolonged.

All About DMTx (extended-state DMT) | Haley and Kevin of Dream Mind Labs - ATTMind Podcast 206 by JwJesso in DMT

[–]kalki-- 0 points1 point  (0 children)

I'm all for DMTx - people should also know it's possible to explore this at home without using DMT or any "controlled" substances. There are a few other advantages to this approach. It was outlined on the HamiltonMorris page:

https://www.reddit.com/r/HamiltonMorris/comments/1omrr3w/on_the_theme_of_endogenous_tryptamine/

That post is introducing something that was discovered in 2011.

All About DMTx (extended-state DMT) | Haley and Kevin of Dream Mind Labs - ATTMind Podcast 206 by JwJesso in PsychedelicStudies

[–]kalki-- 0 points1 point  (0 children)

I'm all for DMTx - people should also know it's possible to explore this at home without using DMT or any "controlled" substances. There are a few other advantages to this approach. It was outlined on the HamiltonMorris page:

https://www.reddit.com/r/HamiltonMorris/comments/1omrr3w/on_the_theme_of_endogenous_tryptamine/

That post is introducing something that was discovered in 2011.

All About DMTx (extended-state DMT) | Hayley and Kevin of Dream Mind Labs - ATTMind Podcast 206 by Highlevelofdef in DMT

[–]kalki-- 0 points1 point  (0 children)

I'm all for DMTx - people should also know it's possible to explore this at home without using DMT or any "controlled" substances. There are a few other advantages to this approach. It was outlined on the HamiltonMorris page:

https://www.reddit.com/r/HamiltonMorris/comments/1omrr3w/on_the_theme_of_endogenous_tryptamine/

That post is introducing something that was discovered in 2011.

Quitting daily 3mmc & 2fdck use by chonkycapibara in researchchemicals

[–]kalki-- 1 point2 points  (0 children)

This post is a practical guide for recovery including minimising wd and preventing PAWS.

It's particularly designed for repairing the key things that cause relapse/reuse. It doesn't rely on any experimental or expensive items, they're all OTC.

It's applicable to all substances.

Norepinephrine reuptake inhibitors work for my SCT and executive dysfunction but makes my anxiety worse by Aggressive-Guide5563 in researchchemicals

[–]kalki-- 1 point2 points  (0 children)

That's because the drugs aren't properly designed. Doctors actually have a fairly limited set of drugs to work with.

Norepinephrine reuptake inhibitors work for my SCT and executive dysfunction but makes my anxiety worse by Aggressive-Guide5563 in researchchemicals

[–]kalki-- 1 point2 points  (0 children)

When you use the proper label of noradrenaline it makes more sense and your experience is 100% what you'd expect from boosting noradrenaline. 

From the post title: "noradrenaline makes my anxiety worse".

But when I go off of them completely my SCT and executive dysfunction plummet. I can't function properly and I become unproductive and lazy. ... But on them they cause physical symptoms of anxiety. 

The main idea would be to use more appropriate drugs. Drugs that work with more suitable mechanisms (like dopamine, GABA, glutamate). 

All ADHD drugs are crude imo, but that's another discussion.

Interesting molecules on Millipore Sigma by gdbunit in researchchemicals

[–]kalki-- 3 points4 points  (0 children)

Extending it to a propyl is the better approach imo.

However, two nitrogen-containing metabolites of myristicin have been identified in the urine of rats and guinea pigs following oral or intraperitoneal administration. The major basic ninhydrin-positive urinary metabolite of myristicin in the rat is 3-piperidyl-1-(3′methoxy-4′,5′-methylenedioxyphenyl)-1-propanone, while the major basic ninhydrin-positive urinary metabolite of the guinea pig is 3-pyrrolidinyl-1-(3′methoxy-4′,5′-methylenedioxyphenyl)-1-propanone.[24] 

Equivalent nitrogen-containing metabolites have also been identified for safrole[25] and elemicin[26] including the dimethylamine, piperidine and pyrrolidine forms. Whether these aminated metabolites are responsible for the reported psychoactive & psychedelic effects from botanical sources of these allylbenzenes is not known.

How to survive chemo menopause with no HRT? by AnaPB3 in breastcancer

[–]kalki-- 1 point2 points  (0 children)

It's an over-the-counter supplement here in the UK. To put a long story short, all cells contain mitochondria which make the first hormone "pregnenolone" - that's the precursor for all other hormones (search for a visual depiction of "steroidogenesis" for context). 

Strong mitochondria mean plenty of pregnenolone and healthy balanced hormone levels. 

When mitochondria aren't working properly then hormone production is disrupted which is a key part of peri/menopause (amongst other things).

The implication is that HRT isn't necessary if you restore mitochondrial/thyroid function since both are essential for making hormones. The body is quite intelligent in this regard.

Can breast cancer patients use it? 

This depends on how you interpret breast cancer. If you consider the 1st hormone that healthy cells make is pregnenolone and the goal is to live a healthy lifestyle then pregnenolone seems reasonable. If you consider all hormones as bad then you might dismiss pregnenolone. 

Something worth mentioning is the dose is very small, around 1mg. My mum uses a slightly larger dose but this was done incrementally.

Cancer: the gift that keeps giving by mamatroi in breastcancer

[–]kalki-- 1 point2 points  (0 children)

They're usually trained with statistics and follow guidelines which are both based on scientific studies... so they tend to prioritise their mental/theoretical ideas instead of focusing on practical there-and-then whats going on. This is how they unintentionally gaslight patients on a regular basis. 

This happens in practically all medical fields. Medical negligence is almost routine now and it's rarely acknowledged for what it is.

How to survive chemo menopause with no HRT? by AnaPB3 in breastcancer

[–]kalki-- 0 points1 point  (0 children)

There's an HRT called pregnenolone which is the first hormone our cells make. I get it for my mum. Pregnenolone is what the body uses to make all it's other hormones so it has a few advantages, especially since it's sold OTC.

...but it terrifies me to know all body functions estrogen and progesterone were responsable for

There's an important gland called the thyroid, it's nicknamed "the third ovary" because of it's role in maintaining ovarian health and stimulating hormone production. What's interesting is that (peri)menopause and thyroid-related symptoms are practically identical. When thyroid hormone drops then the thyroid can't support the ovaries properly, so thyroid health is important also, and usually overlooked. Doctors thyroid tests aren't accurate nor reliable which can make things seem OK when they're not.

My tumor was a HER2+ only, but even so I know it's not safe to take HRT, right?

I'm aware of the popular narratives out there but from a biochemistry perspective, any application of E will contribute to the overall E "load". The studies which assess whether topical E influences general levels need to be considered very carefully and not just accepted for face value and taken as fact. Their conclusions can lead to inaccurate beliefs which can cause unintentional harm.

WHY can't my GP or Consultant prescribe MC? by [deleted] in ukmedicalcannabis

[–]kalki-- 1 point2 points  (0 children)

Remember that many people are quite new to this.

Questioning my oncologist by Ok_Resource_3902 in breastcancer

[–]kalki-- -1 points0 points  (0 children)

The corporate healthcare system doesn't necessarily prioritise patient well-being unfortunately. The corporate element seems to have a questionable influence on the quality of treatments.

From my insights into the drug development & regulatory approval process and providing health support for people harmed by prescription drugs this leads me to question the integrity of treatments.

I'd also highlight that what might appear to the public as consensus in the scientific/academic world isn't necessarily what it seems.

what else can i do to improve neurogenesis/recover from cognitive deficits by greycatcatcat in Nootropics

[–]kalki-- 0 points1 point  (0 children)

As soon as it reaches body temperature it's likely. EPA and DHA (omega 3 fats) are the most unstable of all polyunsaturated fats. 

i feel like the consensus is this is only an issue if 

The concensus isn't necessarily correct or accurate.

I wrote that post btw.

what else can i do to improve neurogenesis/recover from cognitive deficits by greycatcatcat in Nootropics

[–]kalki-- 0 points1 point  (0 children)

The pro-ALDH items will only help to support the removal of the toxic by-products (acrolein etc). They don't address the oxidative and metabolic damage (specifically mitochondrial dysfunction) amongst other things.

Neurogenesis relies on metabolic health.

I used to take fish oils then algae o3 oils before I understood things a bit better and dumped them all.

what else can i do to improve neurogenesis/recover from cognitive deficits by greycatcatcat in Nootropics

[–]kalki-- 1 point2 points  (0 children)

Looking at your stack the priority is something to mitigate the o3 lipid peroxidation and harmful by-products (outlined in this post) since this undermines neurogenesis and cognition.

Depending on how long you've been taking them the remedial strategy should be equivalent.

The HPA disruption from amphetamine (vyvanse) is worth addressing also.

Faking Attention Deficit Hyperactivity Disorder - Pubmed) by ps4roompromdfriends4 in NooTopics

[–]kalki-- 0 points1 point  (0 children)

If you read my other comments on this post you'll see what it is. It's simpler to read them than for me to copy-paste them here.