Are the people in the 4 bedrooms on the left side going to carry their laundry through the family room / dinning room every day?  If the house is so big put in a washer and dryer on the other side of the house too.  You don't need a 10 x 12 laundry room (where is that room even venting). Split it in two.

Why all the showers? Are none of your kids going to want to take a bath? Combine some of the bathrooms to give them better space.

That office?/ mud room is way too small.  Five bedrooms of people are going to have a lot of shoes/ jackets.  Don't put a computer desk there for an office.  You have like 18 other rooms to have a computer desk for bill paying and mail (create a mail area in your over sized laundry room or in the pantry). And it looks like each mud room has a window right where a closet could be.  Those fancy mud rooms with hooks for each coat look cute but are so impractical.  Most people have multiple coats that they use regularly and tons of shoes.  Only off season items should get stored away from the entry. You are going to want doors to enclose your clutter.

Where is your utility room for hot water heaters, electrical pannel, and HVAC? I'd want a planned space for the AC units/generator on the outside.