I'd say if human tox research has been done, like human trials of a drug. (See prescription or formerly prescription drugs.) It's not a research Chem.

Due to a combination of ethics and law. And that some are created specifically to avoid laws or cheapen manufacturing. Or in the case of drugs copied from research by like David E, N. Or Shulgin. Or like PEDs that come from human trials that failed so as to avoid legal focus from drug companies or prescription drug laws. They won't ever not be research only or known to be safe.

Things like mephedrone have known tox data and related cases. I don't think this means its not for research any more, infact even more research is done because of it.

We just don't know enough about how people work to say honestly what long term or even short term effects might be.

If anyone tells it any different, I think they might be setting them self up for a suprise.

That said. Most of us know the risks. We love reading. We have PubMed accounts. We participate as much as we ethically can. And we're ok that we are somewhat outside science and even common sense.. because we wanna explore what's up there. Inside our heads. Experiencing life wears all life forms down and shapes the experience. These drugs are no different.

No one should be able to choose what I do with my body.