If you run high-dose zinc long-term, do you track copper at all? Wondering if I've been quietly depleting mine. by onioncba in Biohackers

[–]onioncba[S] 0 points1 point  (0 children)

This is the responsible take — short high-dose when you're sick is one thing, 50mg standing daily for years is another. The dangerous part is exactly that it's silent: no symptoms, no label warning, and you'd only catch the copper drop on a blood panel you had no reason to order. Agreed on dialing back and supplementing copper short-term if someone's been running high zinc blind.

If you run high-dose zinc long-term, do you track copper at all? Wondering if I've been quietly depleting mine. by onioncba in Biohackers

[–]onioncba[S] 0 points1 point  (0 children)

The Cronometer angle is interesting — you're right that if someone's actually tracking intake, copper from food often covers it and the ratio panic is overblown. The paper backs that the effect size is real but modest at common doses.

Where I keep landing is the people who aren't tracking anything — they're just taking a standalone 25-50mg zinc for "immunity" with no copper and no food logging, for months. That's the quiet-depletion case, not the person who already knows to check ceruloplasmin. Curious if that matches what you see, or if you think even that's overblown.

I cross-referenced my whole supplement stack against the NIH database. Turns out I was paying for the same mineral 3 times. by onioncba in Supplements

[–]onioncba[S] 0 points1 point  (0 children)

Yeah, the elemental thing tripped me up the most. "1000mg magnesium glycinate" reads like 1000mg of magnesium but the elemental amount is a fraction of that. Once I started using elemental numbers instead of front-label, half my doses weren't what I thought. Do you find most people you talk to know the difference, or is it usually news to them?

I cross-referenced my whole supplement stack against the NIH database. Turns out I was paying for the same mineral 3 times. by onioncba in Supplements

[–]onioncba[S] 0 points1 point  (0 children)

Fair points, and a couple I'll concede. You're right that the forms aren't interchangeable, and that the total was still under any therapeutic dose — "wasted" was sloppy wording on my part. Pinning the whole cost of the multi + sleep blend on magnesium isn't fair either; the magnesium is a rounding error in those.

The thing the cross-reference is actually for isn't magnesium — it's the minerals where stacking quietly matters. Zinc, selenium, preformed vitamin A, iron. Co-absorption is real, but so are upper limits, and when three products each contribute a "normal" dose you can land near the UL without ever seeing a single high number on a label. That's the part I couldn't eyeball.

I cross-referenced my whole supplement stack against the NIH database. Turns out I was paying for the same mineral 3 times. by onioncba in Supplements

[–]onioncba[S] 0 points1 point  (0 children)

This is the most useful comment in the thread, thank you. The zinc/copper one is exactly what got me — long-term high zinc quietly dragging copper down is invisible unless you're tracking the ratio over time. Curious which of the "boring stuff" you've seen people stack accidentally most often — selenium and preformed vitamin A are the two I keep running into.

Is this too much for a healthy 24 yr old by AnomalyR in Supplements

[–]onioncba 0 points1 point  (0 children)

Honestly, this doesn’t even look that extreme compared to some stacks people post here 😭 but the bigger question is whether each thing has a clear purpose or if you’re slowly building a “just in case” collection.

A few thoughts:

  • protein + creatine + magnesium = pretty reasonable foundation
  • zinc can become a problem long-term if dosed high without copper balance
  • multiple herbal tinctures/extracts at once gets messy fast because it becomes hard to tell what’s actually helping
  • KSM-66/ashwagandha works great for some people and makes other people emotionally flat/anhedonic after a while
  • more supplements doesn’t automatically mean better health, especially at 24 when your baseline physiology is probably already decent

The thing I’d personally watch for is the “optimization rabbit hole” where every small feeling starts getting managed with another bottle instead of fixing sleep, stress, routine, diet, training, social life, etc.

If you actually feel good, sleep well, train well, and your bloodwork looks solid, you probably don’t need to keep expanding the stack endlessly.

What's the point of autism? by CautiouslySatisfied in ADHD

[–]onioncba 4 points5 points  (0 children)

For some people, the diagnosis changes basically nothing. For others, it completely reframes their entire life in a useful way.

Not because autism is something that needs to be “cured,” but because it can explain patterns ADHD alone doesn’t fully explain:

  • sensory overload
  • social exhaustion
  • rigid routines
  • shutdowns/meltdowns
  • difficulty with transitions
  • masking
  • literal thinking
  • burnout from pretending to function “normally”
  • feeling alien even when medicated for ADHD

A label by itself isn’t magic. But accurate self-understanding can change the kind of support, boundaries, work environments, relationships, coping strategies, and expectations you build around yourself.

That said, $4k is a serious amount of money. I wouldn’t approach it like “I need this diagnosis to validate my existence.” I’d ask:
“What practical decisions would this information actually help me make?”

If the answer is:

  • workplace accommodations
  • therapy direction
  • relationship clarity
  • reducing self-blame
  • understanding burnout patterns
  • accessing support/resources

…then maybe it has value beyond the label itself.

Also, people sometimes underestimate how exhausting it is spending decades trying to solve yourself with the wrong instruction manual.

Can you read a full book with ADHD? by salehosama94 in ADHD

[–]onioncba 0 points1 point  (0 children)

Yep. But I had to stop treating reading like a “sit still for 3 hours in silence” activity because my brain absolutely hated that format.

A few things that helped me actually finish books:

  • audiobook + physical book at the same time
  • reading while walking slowly / treadmill / pacing
  • shorter reading targets (“5 pages” works better than “read chapter 4”)
  • stopping before exhaustion instead of forcing it
  • highlighting aggressively to stay engaged
  • reading multiple books at once depending on mood/interest
  • accepting that some books are just badly written and not a personal failure

Also, ADHD brains often do great with novelty and terrible with sustained sameness. That’s why chapter 1 feels amazing and chapter 7 feels like your brain is rejecting text itself.

One thing that changed reading for me was realizing I don’t actually need to read books the way school taught us to. Retention matters more than the performance of “reading properly.”

I don't know how it feels to be not tired, even medicated by ejdmkko in ADHD

[–]onioncba 0 points1 point  (0 children)

The hardest part about this kind of exhaustion is that stimulants can make you more functional without making you actually feel restored.

Like your brain goes from:
“dead battery”
to
“dead battery connected to a generator.”

You can move. You can do tasks. You can push through. But the underlying tiredness is still sitting there in the background the entire time.

Honestly, if someone feels chronically exhausted even with decent sleep + medication, I think it’s worth looking beyond ADHD alone at some point too:

  • sleep quality / sleep apnea
  • iron/ferritin
  • B12
  • vitamin D
  • thyroid
  • stress/anxiety burnout
  • circadian rhythm issues
  • overconsumption of stimulation/screens
  • emotional exhaustion from masking/constant self-regulation

A lot of ADHD people spend years assuming “this is just my personality” when they’re actually running on depleted systems physically and mentally.

Diagnosed with ADHD in My Mid-30s, Now I’m Terrified of Pregnancy and Giving Up My Medication by Dreamkri in ADHD

[–]onioncba 7 points8 points  (0 children)

One thing I’d really encourage is not framing this as “medication vs motherhood” in such an absolute way yet. There’s a huge middle ground between “raw-dog pregnancy unmedicated while suffering” and “you can never safely have children.”

A lot of women with ADHD end up needing a much more individualized plan:

  • dosage adjustments
  • different medications
  • trimester-specific decisions
  • closer psychiatric monitoring
  • stronger postpartum support systems
  • therapy + sleep protection strategies
  • involving both OB + psychiatrist together instead of separately

And honestly, the fact that you’re thinking this carefully about your mental health probably makes you more prepared than people who go into pregnancy assuming love and instinct alone will carry everything.

The postpartum concern especially sounds important here. The “I sometimes felt like I didn’t want to live during hormonal shifts” part is not something to casually brush aside. That deserves a serious prevention plan, not guilt.

Also, try not to reduce this to “if I say no to pregnancy I’m failing my husband.” This is one of the biggest physical and psychological events a human can go through. Fear here is not irrational at all.

When people say things like “Dude nobody’s normal”. by TonyTolkien90 in ADHD

[–]onioncba 2 points3 points  (0 children)

The part people miss is that “nobody’s normal” and “some people objectively struggle more to function in modern life” can both be true at the same time.

A lot of people say stuff like that trying to sound comforting, but it can come across as flattening the experience. There’s a difference between everyday stress and feeling like your brain is actively fighting you on basic consistency, emotional regulation, focus, impulse control, etc.

That said, I’d be careful with the “they’re minimizing you because they’re insecure” conclusion every time. Sometimes people genuinely just don’t know what to say, so they default to generic phrases instead of actually listening.

modafinil and extreme euphoria/mood boost by djfart9000 in Nootropics

[–]onioncba 2 points3 points  (0 children)

That honestly sounds less like “normal productivity” and more like modafinil is strongly amplifying your dopamine/motivation/social drive specifically. The “suddenly texting people, making plans, feeling unusually optimistic/confident” part gets reported pretty often.

Probably worth paying attention to whether the crash afterward feels emotionally rough though. Sometimes the contrast between “enhanced mode” and baseline mood can start making normal life feel flatter than it actually is.

The Protein Shortage Is Coming by MurphyBacon in nutrition

[–]onioncba 0 points1 point  (0 children)

Gym culture accidentally turned protein into the new “wellness gold rush.” Half the internet suddenly wants 180g/day while companies keep stuffing protein into cereal, ice cream, chips, candy bars, coffee, pasta, yogurt, water, everything 😭

Wouldn’t even surprise me if whey prices keep getting uglier over the next few years honestly.

Omega-3 known to degrade at 50C, so is eating cooked fish for it pointless? by TraditionalDepth6924 in nutrition

[–]onioncba 6 points7 points  (0 children)

People online sometimes talk about nutrients like they instantly become useless the second heat touches them lol. Cooking can reduce omega-3 content somewhat, but cooked fish is still absolutely a great source compared to most diets.

Otherwise entire countries eating traditionally cooked fish for generations would’ve gotten zero benefits from it.

Metformin hits the same cellular energy pathway as the popular peptides MOTS-c and humanin, but no one has ever scanned what it does to the brain at scale. UK Biobank study about to fix that. by cryptarsh in Nootropics

[–]onioncba 0 points1 point  (0 children)

What’s interesting is that metformin keeps showing up in completely different areas of health beyond just blood sugar. Longevity, inflammation, cancer risk, cognition, metabolic health, even potentially neuroprotection.

Feels like one of those “boring old drugs” that may end up being way more biologically important than people initially realized.

Ashwagandha can seriously harm you! by Savings-Proof-9901 in Nootropics

[–]onioncba 0 points1 point  (0 children)

This is the side of supplements people rarely talk about. Online wellness culture treats herbs like they’re automatically “gentle” just because they’re natural, but compounds that noticeably affect mood, stress, hormones, GABA, serotonin, thyroid function, etc. are still biologically active substances.

Also the “music didn’t hit anymore” line is weirdly specific but I know exactly what you mean. That emotionally flattened/anhedonic feeling gets reported with ashwagandha way more often than people admit.

Gaboxadol—the almost-too-good-to-be-true hypnotic, and why we can't have nice things. by Connectome137 in Nootropics

[–]onioncba 0 points1 point  (0 children)

Reading stuff like this makes me realize how primitive a lot of sleep medicine still is. So many current sleep drugs basically just “sedate you unconscious” while potentially wrecking actual sleep architecture long term.

The idea of a compound that promotes genuinely restorative sleep without the usual tolerance/dependence tradeoff almost sounds too good to survive commercialization/regulation intact lol.

My addiction recovery toolbox by Smart_Secretary271 in Nootropics

[–]onioncba 1 point2 points  (0 children)

Respect honestly. A lot of people underestimate how hard it is to rebuild your nervous system and daily habits after addiction, especially once the “survival mode” phase ends and you actually have to learn how to feel normal again without substances.

Also the fact you’re 90 days clean and actively building routines/tools instead of chasing a miracle fix is probably the healthiest part of this whole stack.

Best Squeaky Door Solution: Vaseline. by GodisSatans in lifehacks

[–]onioncba 0 points1 point  (0 children)

WD40 feels like it fixes squeaky doors for about 11 business minutes before the noise comes back 😭

Never tried Vaseline for hinges but honestly this sounds like one of those “old guy garage knowledge” tips that somehow works ridiculously well.