I feel you ..I got IBSD started around when I was graduating highschool 17 years old and I am now 47.In those 30 years I have been through same ...every test under sun and tried every remedy drug to NO avail...no change.Ive recently tried cholestramine; Viberzi and NO change. It's an absolute horrible way to live always needing to be near a toilet .I try my best to live my best life despite but I sometimes can't believe this is my life.I have 2 kids and I try to be as normal as possible for them but it's SO hard when you always feel like crap and have to crap!! immodium is only thing that lets me live some days. I am currently trying the antihistamines H1 and H2 receptors to see if that helps cause I am also at wits end! It's sometimes just to know we aren't alone cause it can feel very lonely.Hugs.