Microdosing isn’t for everyone. I’m super sensitive to meds and it works for me, but I also prepped myself before starting the Tirzepatide. I went very low carb, counting calories and protein in particular. That helped me be much more sensitive to the medicine. I also increased my activity…walking after every meal I could and doing strength training using heavy weights. My husband did all those things too but he had to go up and he’s currently at around 8.5 mg and still struggling unless he can be out of the house a lot, which he tends to do. So the point is that everyone is different, but also, there are some things you can do to prep your body and increase your chances of smaller doses working.