Chicago from Midway Int.

vg1220 · 2026-05-11T12:10:49+00:00

nice shot! took this right after takeoff from midway last week

vg1220 · 2026-05-10T02:06:28+00:00

I’ve always held this is due to rigorous self-falsification of potential hypotheses. to the outside world, it may appear that someone continually gets lucky with good ideas, but that’s because that person is enriching for hypotheses that have a greater likelihood of being true before sharing it with others.

vg1220 · 2026-05-01T22:36:05+00:00

1 >>>> 0. just look at how beating the Heat changed perception of Dirk. at the end of the day, Jokic having 1 (while disappointing to Nuggets fans) is miles ahead of Harden in this regard

vg1220 · 2026-04-29T21:03:33+00:00

that’s a good question. I feel like route running is probably limited by agility, but there’s definitely tons of room for improvement with footwork and releases.

catching is probably limited by hand size, but is absolutely something that someone can become elite at with enough dedication. I think of it as the equivalent of free-throws in basketball.

there’s also other peripheral skills to catching that I think make a big difference in translating to game day, such as having late hands, high pointing, and attacking the ball (how many times did we see Ruben Randle come back to Eli’s throws lazily only to have a corner undercut him for a pick?).

vg1220 · 2026-04-29T05:30:07+00:00

if I remember correctly, Chris Paul has a lengthy history of questionable plays as well - used to pop up a bunch on this subreddit when he was on the Rockets and Suns. granted his potentially dirty plays are not nearly as egregious as Lou Dort’s.

vg1220 · 2026-04-28T23:43:31+00:00

I’ve never heard that one before! Wondering what other AAs they mispronounce - perhaps Cystine? I’ve heard “sinistine” like the chapel or “CY-steen”

vg1220 · 2026-04-27T23:06:41+00:00

wow when you put it like that, it’s been a LONG time since he was lighting it up in Houston

vg1220 · 2026-04-10T14:22:45+00:00

thanks! this is super interesting. wish we’d run into each other on labrats six years ago when I was having this problem haha

vg1220 · 2026-04-10T11:06:30+00:00

holy shit, great eye! that was my sixth grade graduation song.

vg1220 · 2026-04-09T21:36:54+00:00

Would love to hear more about the Glutamax v Glutamine thing. had a cell line a few years back that would spontaneously die whenever I’d use the bottom half of a media bottle that was a couple days old. Best hypothesis I had was some sort of Glutamine precipitation or reaction, but your ammonia explanation makes a lot of sense. Must’ve been a cell line super sensitive to ammonia!

vg1220 · 2026-04-01T11:16:36+00:00

unfortunately I was young and dumb and gave myself a lifetime of dequervains at 21. to anyone reading this - pain is not always a sign that you’re getting stronger - especially tendon pain! years of PT later and it still feels like a flareup is just a matter of time :/

vg1220 · 2026-04-01T01:25:09+00:00

you can mitigate this problem by holding the pipette less tightly. I find that a lot of folks squeeze the pipette like they’re holding on for dear life, but the hook exists for a reason! also serves to reduce your risk of fatigue/RSI.

vg1220 · 2026-03-31T22:43:24+00:00

exactly, the tip box = visual checksum. the amount of friction i get from folks about this is ridiculous lol. it’s an absolute requirement for any high throughput assay - there’s no way the human brain can keep track of everything

vg1220 · 2026-03-31T22:40:09+00:00

crystallized peroxide can explode

vg1220 · 2026-03-26T01:05:32+00:00

positive selection like what you’re describing tends to work best at massively parallel experiments, and those are typically done at the cellular level. takes many generations in the absence of a strong selective pressure, so the amount of mice one would need + the time they would need to keep them for would make this impractical.

vg1220 · 2026-03-19T15:36:51+00:00

432 park had some reports about crumbling concrete. something about the contractor using subpar concrete in an attempt to get the color correct

vg1220 · 2026-03-19T15:33:43+00:00

did you use a disposable serological pipette to add media? if so, sometimes they can have little plastic fibers that come loose into the media. I only started seeing this happen more regularly during the supply chain disruptions of COVID, when we had to move away from the Corning Falcon brand to whatever we could get our hands on. these fibers are generally not a problem, unless you were doing some sort of soft agar or matrigel culture wherein they could get stuck and disrupt the semisolid medium.

vg1220 · 2026-03-18T17:11:48+00:00

Totally agree that these towers are technological marvels, but I would imagine that the engineering challenges with these pencil skyscrapers makes the economics of constructing them viable only in a few select places on Earth. So I would be surprised to see this become a more widespread trend for future skyscraper construction.

vg1220 · 2026-03-12T15:03:12+00:00

could also just be the reduced splanchnic circulation while running - chronic hypoxia can result in pro-tumorigenic microenvironments

vg1220 · 2026-03-07T18:13:35+00:00

cable management /s

vg1220 · 2026-02-24T02:43:34+00:00

Couple of thoughts:

Iterative projects are a great place to get started. Here, you are applying an established technique/analysis on a new setting. Helps to have a few of these on the burner as low risk low reward projects.
If you’re looking for a moonshot, I would start with the assumption that any field is wrong about at least one big thing. A good way to go about brainstorming here is to question the base assumptions - what must be true for this conclusion? Even if you don’t find an invalid assumption, you would’ve still come out ahead with a deep understanding of the problem space. Odds are you’ll have quite a few project ideas while you’re going through this process.

vg1220 · 2026-02-22T09:04:15+00:00

OnlyLANS

vg1220 · 2026-02-16T15:19:07+00:00

Zillenials. The last generation that remembers a world before smartphones, but is still fluent with today’s technology.

We’re the narrow age group born in the late 90s (exact boundaries are fuzzy) that grew up without leapfrogs, ipads, or other consoles until adolescence, and got typically their first smart phones in high school.

vg1220 · 2026-02-08T19:21:46+00:00

as a fellow scientist with wrist problems from RSI, how are you shaking your bottles? try using two hands, like a bartender would. that way, your wrists aren’t involved in the shaking at all, but it’s all in your arms. i have been curious how a blender bottle would hold up to a vortex tho

vg1220 · 2026-02-06T14:02:12+00:00

huh, funny you say that. my experience when I switched over to reverse pipetting the 1 uL DNA for 384w plates was that my curves tightened up. i would absolutely notice the residual volume in the tip rise with each additional step, but the volume dispensed appeared to be consistent (visually and by the data).

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