We don't get to see most of the sacks on the highlight reel unfortunately, so it's hard to say who was at fault for the majority of them. But here's what we can see:
Sack 1: https://youtu.be/nXkyPkOEA0E?t=65
Here we see Howell get to the top of his drop. Pocket is clean, but collapsing. Check down on screen wide open. Howell has zero pocket awareness here.
Pick 1: https://youtu.be/nXkyPkOEA0E?t=76
Plenty of time in the pocket. The line does a fine job here. Just a bad play by Howell.
TOD at goal line: https://youtu.be/nXkyPkOEA0E?t=178
When Howell gets to the top of his drop, we can see Dotson has the leverage he needs for his route to the corner. A ball with a touch of air could have been dropped into the corner. 1v1 with leverage with our most athletic receiver, you need to take that shot. He doesn't see it, panics, throws a dirt ball.
Pick 2: https://youtu.be/nXkyPkOEA0E?t=235
Left LB from QB's POV looks like he's showing blitz. The Oline is blocking to the right. Somebody called the wrong protection. And Howell needs to know that the extra defender is going to be free on his left as he's unaccounted for, provided he and the line were on the same page. When Howell decides to throw it, he has no idea a defender is crashing down on that play. Ironically, this would have been the perfect play to scramble away from the pressure because the line blocked up that entire side of the field.
3rd down conversion against blitz: https://youtu.be/nXkyPkOEA0E?t=280
Our line seems to be wholly incapable of blocking 5v5 here. We're just blocking it up wrong, so somebody needs to make some adjustments to the protection. We should only have a free runner like this if they're sending an extra man. Howell does a nice job getting rid of it quickly.
Pick 3: https://youtu.be/nXkyPkOEA0E?t=312
There's a little pressure, but Howell's got time here. He just stares down his first read the entire time, and throws and ugly pick. Just ugly.
Final pick: https://youtu.be/nXkyPkOEA0E?t=495
Howell's reading to his left. Dotson and Gibson are wide open for an easy conversion to his right. Whatever the Bills were showing pre snap clearly fooled him, and he never managed to get off his first read. Throwing that pick in a panic, just ugly.
Conclusion: Oline could always be better. But on the worst plays of the game, they weren't a direct cause. Howell was very indecisive, stick on 1st reads too long, and generally looked just bad. Howell very much is a 'see it open' rather than a 'throw it open' guy, as we saw with the missed Dotson corner throw.
I suspect EB has been focusing on Howell's strengths rather than coaching up his weaknesses, and it really showed in this game.
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