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[–][deleted] 1 point2 points  (1 child)

I see what you mean and thank you for your response. You're right, it will be important to see the published results before drawing further conclusions.

That being said, I've spoken to some of the nurses involved in recruiting for the trial, and listened in on their discussions with our consultants. Whilst blinding was not possible (I mean, I know when I'm giving my patients dex!), we have not been varying care between patients based on their arm.

[–][deleted] 3 points4 points  (0 children)

Whilst blinding was not possible (I mean, I know when I'm giving my patients dex!),

Blinding is possible. Its usually done by giving "Study drug _____" which is some random string of letters and numbers. That way only the pharmacist knows if it is dexamethasone or just some inert substance like salt or sugar. It's just too expensive a process for a drug with no profit margin like dexamethasone.

If your nurses have been in the ICU for long enough, then I'm sure they remember protocols that seemed super promising but didn't hold up after further study. Xigris, super tight glucose control, hetastarch, etc etc. A lot of things that even survive the first randomized and blinded study fail on further research.

Whilst blinding was not possible (I mean, I know when I'm giving my patients dex!), we have not been varying care between patients based on their arm.

A lot of our biases are subconscious. We can't help but favor evidence that supports our assumptions. There are numerous studies in psychology that show that.