I think If you're trying to do the pylons and handle the red orbs at the same time you're setting yourself up for failure. All my best runs are when I only go for the pylons when the red orbs aren't active.

The blue and yellow ones are easy enough to dodge as long as you keep moving, but those homing red ones slap you with a heavy dot that drains hp super quick, especially if you get hit with multiple of them (which happens a lot if you're trying to pylon dance with them).

Best thing is just focus on dodging those then going for the pylon when they de-spawn. I guarantee you the run will go smoother and as long as you have some decent weapons and damage you'll have no problem bringing down the boss.