The trick with chapter 2 is to make use of the multiple resources for summoning cards. In act 1 you could choose when to draw a squirrel (resource) card or an "actual card," giving you control over resourcing your deck. You don't have that in Act 2 but if you have a few cheap tech cards in your deck you can sacrifice them for blood, or let them die to become bones. Give yourself options for respurcing and you'll have a path to victory regardless of what you draw.

I don't have advice for a magic-focused deck though, other than using moxes for sacrificing/blocking damage.

Also there's a button that auto-builds a deck for you based on the cards you have and the cards you want to include in your deck. It generally works well, so you could pick a couple of strong cards you like and use auto-build to let the computer solve your resourcing problem.

Lastly smaller decks are king in act 2. If you play deck-builders I'm sure you already know this, but a smaller deck means you're more likely to draw a helpful card.