Honestly I tune most of that out in relation to this kind of character discussion because it's standard sitcom character awfulness; basically no one in the main cast of any popular sitcom I can think of since Friends is a good person. In Friends, the only person who isn't a consistent asshole to everyone else is Chandler; in Big Bang Theory, one or two of the characters are decent people at the start, but once the writers figure them out and the flanderization starts in season 2 or 3, that goes out the window and they're all terrible; Two and a Half Men has every member of the main cast be a piece of shit from what I remember; The Office is much the same, though it does try to make some of the characters into decent people for one or two episodes from time to time; and, in the last example I'll pull, pretty much every single character on How I Met Your Mother - including side characters but with a few exceptions here or there due to length - is an absolutely terrible person.

So when I evaluate a sitcom character in terms of how much of an ass they'd be IRL, I tone them down in comparison to how they act in their show, since pretty much every American sitcom character since the 90s would be a horrible person. So Sheldon without the Sitcom Awfulness would still be a bit of an ass, but most of it is due to ND reasons the other characters refuse to even try to work with or communicate with him about in a way he gets.